VI-60
VI-60 is a dual, orally active inhibitor of cPLA2 and COX-2, which reveals an anti-inflammtory efficacy through the inhibition of p38 MAPK/cPLA2/COX-2/PGE2 pathway.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3050874-42-2
- 分子式: C37H43F3O3
- 分子量:592.73
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Phospholipase アイソフォーム固有の製品をすべて表示
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生物活性
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COX-2 |
cPLA2 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
3.85 μM
Compound: VI-60
|
Antiinflammatory activity in LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by griess reagent based assay
Antiinflammatory activity in LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by griess reagent based assay
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[PMID: 38286094] |
VI-60 (10 μΜ, 24-48 h) inhibits the LPS-induced inflammatory mediators NO (IC50 is 3.85 μM) and PGE2 production without significant cytotoxicity in RAW264.7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7
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Concentration:30 μΜ
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Incubation Time:24-48 h
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Result:Exhibite cell viability of nearly 100%, in compare to the verhicle group.
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Cell Line:RAW264.7
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Concentration:30 μΜ, 2.5-10 μM
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Incubation Time:30 μM for 2 h, 2.5-10 μM for 1 h
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Result:Downregulated the phosphor-p38-MAPK, cPLA2 and COX2, stabilized the cPLA2 and COX2 proteins when heated.
VI-60 (20 mg/kg, p.o., everyday) regulates the balance between Th17 and Tregs and reduces IL-17 expression through inhibition of the p38 MAPK/cPLA2/COX-2/PGE2 pathway[1].
VI-60 exhibits a low ulcerative potential (50 mg/kg), no hepatotoxicity or nephrotoxicity (20 mg/kg, p.o.) in Wistar rats .
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adjuvant-induced arthritis in Lewis rats[1]
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Dosage:20 mg/kg
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Administration:p.o., every 24 h or 48 h for 20 days
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Result:Inhibited the weight loss and the edema of paws, increased the mechanical withdrawal threshold (MWT), decreased the spleen weights.
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Animal Model:Male mistar rats[1]
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Dosage:20 mg/kg
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Administration:p.o., for 3 days
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Result:Revealed identical indexes of glutamic pyruvic transaminase (GPT), glutamic oxalacetic transaminase (GOT), and blood urea nitrogen (BUN) as of normal rats.
化学情報
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CAS 番号 3050874-42-2
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分子量 592.73
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分子式 C37H43F3O3
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SMILES
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CC/C=C(C(F)(F)F)/OC(C(C)C1=CC=C(C(C2=CC=CC=C2)=O)C=C1)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
VI-60 関連分類
HY-162228 関連分類
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