Xipamide
Based on 1 publication(s) in Google Scholar
Xipamide is an orally active carbonic anhydrase (CA) inhibitor and Na+/Cl--potassium cotransporter inhibitor, with diuretic and antihypertensive effects. Xipamide reduces NaCl reabsorption by inhibiting the Cl-/NaCO3- anion exchanger, promoting potassium and magnesium excretion while increasing calcium reabsorption. Xipamide is cleared primarily via the renal route and causes a transient decrease in glomerular filtration rate under specific conditions. Xipamide can be applied in research related to cardiovascular diseases, hypertension, advanced renal failure, and cirrhosis with ascites.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.74%
- CAS 番号: 14293-44-8
- 分子式: C15H15ClN2O4S
- 分子量:354.81
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Xipamide
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生物活性
製品説明
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CAs |
体外実験
Xipamide (15 min) reduces Amiloride-induced acidification at concentrations similar to its effective concentrations in H9c2 cells, achieving 70-80% maximal inhibition in neonatal rat cardiomyocytes[1].
Xipamide (90 min) inhibits the DIDS-sensitive LiCO3− influx anion exchanger in fresh human erythrocytes, with an IC50 of 25 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 14293-44-8
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性状 Solid
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分子量 354.81
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分子式 C15H15ClN2O4S
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Color White to off-white
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SMILES
O=C(NC1=C(C)C=CC=C1C)C2=CC(S(=O)(N)=O)=C(Cl)C=C2O
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別名
キシパミド
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
体外:
DMSO : 250 mg/mL (704.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (5.86 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (5.86 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (288 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8184 mL | 14.0920 mL | 28.1841 mL | 70.4602 mL |
| 5 mM | 0.5637 mL | 2.8184 mL | 5.6368 mL | 14.0920 mL | |
| 10 mM | 0.2818 mL | 1.4092 mL | 2.8184 mL | 7.0460 mL | |
| 15 mM | 0.1879 mL | 0.9395 mL | 1.8789 mL | 4.6973 mL | |
| 20 mM | 0.1409 mL | 0.7046 mL | 1.4092 mL | 3.5230 mL | |
| 25 mM | 0.1127 mL | 0.5637 mL | 1.1274 mL | 2.8184 mL | |
| 30 mM | 0.0939 mL | 0.4697 mL | 0.9395 mL | 2.3487 mL | |
| 40 mM | 0.0705 mL | 0.3523 mL | 0.7046 mL | 1.7615 mL | |
| 50 mM | 0.0564 mL | 0.2818 mL | 0.5637 mL | 1.4092 mL | |
| 60 mM | 0.0470 mL | 0.2349 mL | 0.4697 mL | 1.1743 mL | |
| 80 mM | 0.0352 mL | 0.1762 mL | 0.3523 mL | 0.8808 mL | |
| 100 mM | 0.0282 mL | 0.1409 mL | 0.2818 mL | 0.7046 mL |
Xipamide 関連分類
HY-W042301 関連分類
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Keywords
- Xipamide
- 14293-44-8
- Anion Exchangers
- Carbonic Anhydrase
- Endothelin Receptor
- Carbonate dehydratase
- CO2 hydration
- DIDS-sensitive LiCO3? influx
- K+/Cl? co-transport
- Na+/K+ co-transport
- anion-exchange inhibitor
- carbonic anhydrase inhibitor
- cardiovascular diseases
- catalytic zinc site
- hepatic urea synthesis
- sodium-dependent chloride/bicarbonate exchange
- Inhibitor
- inhibitor
- inhibit