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製品番号: HY-182582

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ZY12201

ZY12201 is a selective and orally active TGR5 agonist and pan-CYP inhibitor. ZY12201 lowers glucose levels. ZY12201 induces enzymes regulated through Aryl Hydrocarbon Receptor, Constitutive Androstane Receptor, and Pregnane X Receptor. ZY12201 can be used for the research of type 2 diabetes.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 1430210-54-0
分子式: C₃₁H₃₁FN₄O₃S
分子量:558.67

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

ZY12201 構造式

CAS 番号: 1430210-54-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Cellular Effect
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Cytochrome P450 アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	EC₅₀	0.057 nM Compound: 6g	Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay	[PMID: 26819665]

体外実験

ZY12201 potently activates human TGR5 with an EC₅₀ of 57 pM and mouse TGR5 with an EC₅₀ of 62 pM^[1].
ZY12201 (0.1-100 μM; 48 h) induces CYP1A2, CYP2B6, and CYP3A4 mRNA levels in single female donor HH1103 sandwich cultured human hepatocytes, acting as an agonist of AhR, CAR, and PXR^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

ZY12201 (7.9-29.2 mg/kg) exhibits glucose-lowering activity in diet-induced obese C57BL/6 mice during an oral glucose tolerance test, with an ED₅₀ of 7.9 mg/kg and ED₉₀ of 29.2 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1430210-54-0
分子量 558.67
分子式 C₃₁H₃₁FN₄O₃S
SMILES

FC1=CC=C(N2C(SCCOC3=CC=C(N4C=NC=C4)C=C3)=NC=C2C(C)(C)C5=CC=C(C(OC)=C5)OC)C=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Joshi, VM, et al. Practical and Efficient Synthesis of 2-Thio-imidazole derivative - ZY12201: A Potent TGR5 Agonist. Org. Process Res. Dev. 2020; 24(8):1508-1514.

[2]. Aluri KC, et al. Aminobenzotriazole inhibits and induces several key drug metabolizing enzymes complicating its utility as a pan CYP inhibitor for reaction phenotyping. Clin Transl Sci. 2024;17(3):e13746. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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生物活性
- 製品説明
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

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ZY12201

Cytochrome P450 アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

ZY12201 関連分類

HY-182582 関連分類