IDN-1965
IDN-1965 is an irreversible, broad-spectrum caspase inhibitor. IDN-1965 prevents downstream apoptotic events (such as DNase activation) and significantly delays cytochrome c release by inhibiting caspase activity. IDN-1965 significantly delayed death in mice with cardiomyocyte apoptosis. IDN-1965 completely prevents left ventricular dilation, systolic dysfunction, and fibrosis in mice with dilated cardiomyopathy. IDN-1965 can be used to study apoptosis-related diseases such as heart failure and the mechanisms of apoptosis initiation.
For research use only. We do not sell to patients.
- CAS No.: 204919-14-2
- Formula: C21H26FN3O5
- Molecular Weight:419.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Caspase Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | IC50 |
1.3 μM
Compound: 2
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Inhibitory concentration against JFas cells
Inhibitory concentration against JFas cells
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[PMID: 16250635] |
| THP-1 | IC50 |
10 μM
Compound: 2
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Inhibitory concentration against THP-1 cells
Inhibitory concentration against THP-1 cells
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[PMID: 16250635] |
Chemical Information
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CAS No. 204919-14-2
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Molecular Weight 419.45
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Formula C21H26FN3O5
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SMILES
O=C(CC(C(CF)=O)NC([C@H](C(C)C)NC(C(N1C)=C(C2=C1C=CC=C2)C)=O)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Wencker D, et al. A mechanistic role for cardiac myocyte apoptosis in heart failure. J Clin Invest. 2003 May;111(10):1497-504. [Content Brief]
[2]. Marsden VS,et al. Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome. Nature. 2002 Oct 10;419(6907):634-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IDN-1965 Related Classifications
HY-120257 Related Classifications
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