Phortress
Based on 1 Customer Validation
Phortress is a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1.
For research use only. We do not sell to patients.
- Purity: 98.19%
- CAS No.: 328087-38-3
- Formula: C20H25Cl2FN4OS
- Molecular Weight:459.41
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
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Biological Activity
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CYP1 |
Chemical Information
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CAS No. 328087-38-3
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Appearance Solid
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Molecular Weight 459.41
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Formula C20H25Cl2FN4OS
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Color Light yellow to yellow
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SMILES
O=C(NC1=CC=C(C2=NC3=CC(F)=CC=C3S2)C=C1C)[C@@H](N)CCCCN.[H]Cl.[H]Cl
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Synonyms
NSC 710305
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 125 mg/mL (272.09 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Bradshaw TD, et al. In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles. Br J Cancer. 2002 Apr 22;86(8):1348-54. [Content Brief]
[2]. Bradshaw TD, Westwell AD. The development of the antitumour benzothiazole prodrug, Phortress, as a clinical candidate. Curr Med Chem. 2004 Apr;11(8):1009-21. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1767 mL | 10.8835 mL | 21.7670 mL | 54.4176 mL |
| 5 mM | 0.4353 mL | 2.1767 mL | 4.3534 mL | 10.8835 mL | |
| 10 mM | 0.2177 mL | 1.0884 mL | 2.1767 mL | 5.4418 mL | |
| 15 mM | 0.1451 mL | 0.7256 mL | 1.4511 mL | 3.6278 mL | |
| 20 mM | 0.1088 mL | 0.5442 mL | 1.0884 mL | 2.7209 mL | |
| 25 mM | 0.0871 mL | 0.4353 mL | 0.8707 mL | 2.1767 mL | |
| 30 mM | 0.0726 mL | 0.3628 mL | 0.7256 mL | 1.8139 mL | |
| 40 mM | 0.0544 mL | 0.2721 mL | 0.5442 mL | 1.3604 mL | |
| 50 mM | 0.0435 mL | 0.2177 mL | 0.4353 mL | 1.0884 mL | |
| 60 mM | 0.0363 mL | 0.1814 mL | 0.3628 mL | 0.9070 mL | |
| 80 mM | 0.0272 mL | 0.1360 mL | 0.2721 mL | 0.6802 mL | |
| 100 mM | 0.0218 mL | 0.1088 mL | 0.2177 mL | 0.5442 mL |
Phortress Related Classifications
HY-103223 Related Classifications
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