4-CPPC
Based on 1 Customer Validation
4-CPPC is a selective MIF-2 inhibitor with a Ki of 33 µM. 4-CPPC inhibits the COX2/PGE2 pathway, reduces the levels of COX2 and mPGES-1, and decreases the production of PGE2. 4-CPPC attenuates the formation of early atherosclerotic lesions in hyperlipidemic mice, and lowers the levels of circulating inflammatory cytokines and chemokines. 4-CPPC inhibits MIF-2-triggered cell migration. 4-CPPC improves hindlimb motor function in rats with contusion-induced spinal cord injury. 4-CPPC can be used in studies related to atherosclerosis and spinal cord injury.
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- Purity: 98.20%
- CAS No.: 29553-70-6
- 화학식: C14H9NO6
- 분자량:287.22
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
|
MIF-2 33 μM (Ki) |
MIF-1 431 μM (Ki) |
COX-2 |
4-CPPC (4-160 nM; 1 h) dose-dependently inhibits MIF-2-induced chemotactic migration of primary peripheral blood mononuclear cells[1].
4-CPPC (100 μM; 24 h) inhibits D-DT-induced activation of the COX2/PGE2 pathway in primary astrocytes, reduces the protein levels of COX2 and mPGES-1, and decreases PGE2 production[2].
4-CPPC competitively inhibits the tautomerase activity of MIF-2 with a Ki value of 33 μM, and exhibits 13-fold selectivity over MIF-1[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 background (male, 8 weeks old, atherosclerotic model via cholesterol-rich high-fat diet)[1]
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Dosage:5 mg/kg
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Administration:i.p.; three times per week; 4.5 weeks
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Result:Markedly reduced aortic root atherosclerotic lesion area.
Reduced lesional CD68-positive macrophage area.
Reduced plasma levels of IL-1α, IL-6, IL-15, and IFN-γ.
Chemical Information
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CAS No. 29553-70-6
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Appearance Solid
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분자량 287.22
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화학식 C14H9NO6
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Color White to off-white
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SMILES
O=C(C1=NC=C(C(O)=O)C(C2=CC=CC(C(O)=O)=C2)=C1)O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 100 mg/mL (348.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4817 mL | 17.4083 mL | 34.8165 mL | 87.0413 mL |
| 5 mM | 0.6963 mL | 3.4817 mL | 6.9633 mL | 17.4083 mL | |
| 10 mM | 0.3482 mL | 1.7408 mL | 3.4817 mL | 8.7041 mL | |
| 15 mM | 0.2321 mL | 1.1606 mL | 2.3211 mL | 5.8028 mL | |
| 20 mM | 0.1741 mL | 0.8704 mL | 1.7408 mL | 4.3521 mL | |
| 25 mM | 0.1393 mL | 0.6963 mL | 1.3927 mL | 3.4817 mL | |
| 30 mM | 0.1161 mL | 0.5803 mL | 1.1606 mL | 2.9014 mL | |
| 40 mM | 0.0870 mL | 0.4352 mL | 0.8704 mL | 2.1760 mL | |
| 50 mM | 0.0696 mL | 0.3482 mL | 0.6963 mL | 1.7408 mL | |
| 60 mM | 0.0580 mL | 0.2901 mL | 0.5803 mL | 1.4507 mL | |
| 80 mM | 0.0435 mL | 0.2176 mL | 0.4352 mL | 1.0880 mL | |
| 100 mM | 0.0348 mL | 0.1741 mL | 0.3482 mL | 0.8704 mL |
4-CPPC Related Classifications
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