Dinotefuran
Based on 4 publication(s) in Google Scholar
Dinotefuran is an orally active and competitive inhibitor and insecticide targeting insect nicotinic acetylcholine receptors (nAChRs). Dinotefuran blocks neural signaling and induces neural dysfunction in insects. Dinotefuran binds to [3H]epibatidine in the neural cord membrane of American cockroach with an IC50 of 890 nM and to [3H]α-bungarotoxin with an IC50 of 36.1 μM. Dinotefuran exhibits knockdown activity (KD50=0.351 nmol/g) and lethal activity (LD50=0.173 nmol/g) against German cockroach. Dinotefuran is mainly used for agricultural pest control, such as field control of piercing-sucking and chewing insects (e.g., aphids, planthoppers), while its environmental toxicological effects (e.g., oxidative stress and reproductive neurotoxicity on earthworms) are also a research focus to assess ecological risks.
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- Purity: 99.74%
- CAS No.: 165252-70-0
- 화학식: C7H14N4O3
- 분자량:202.21
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Publications Citing Use of MedChemExpress (MCE) Dinotefuran
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Biological Activity
Dinotefuran (1 μM; 120 min) competitively inhibits the binding of [3H]EPI to nicotinic acetylcholine receptors (nAChRs) in the neuronal cord membrane of American cockroaches[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Periplaneta americana nerve cord membrane preparations
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Concentration:IC50: 890 nM ((±)-Dinotefuran); 856 nM ((+)-Dinotefuran); 1890 nM ((-)-Dinotefuran)
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Incubation Time:120 minutes
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Result:Inhibited [3H]EPI binding with an IC50 of 890 nM, with (+)-enantiomer being ~2-fold more potent than (-)-enantiomer.
Dinotefuran (0.015%-0.06%; mixed in feed; daily intake) leads to prolonged movement time of F0 males, decreased fertility of females, increases birth weight and imbalanced sex ratio of F1 pups, delayes olfactory orientation of female offspring, decreases movement distance and speed of male offspring, and increased urination frequency[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Toxicity model in CD-1 mouse (4-week-old)[2]
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Dosage:0% (control), 0.015%, 0.03%, and 0.06%
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Administration:Oral, given in the basal diets (CE-2); 5 weeks of age of the F0 generation to 11 weeks of age of the F1 generation in mice.
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Result:In F0 adult males, movement time during exploratory behavior significantly increased with dose-related trends), while rearing time and average rearing time decreased.
In F1 offspring, litter size and weight at birth increased in dose-related trends), but sex ratio (male/female) decreased significantly.
On postnatal day (PND) 21, offspring body weight increased in both sexes for males, for females).
Female offspring showed delayed olfactory orientation time on PND 14, while male offspring exhibited reduced total distance, average speed, and increased defecation frequency and urination.
Chemical Information
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CAS No. 165252-70-0
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Appearance Solid
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분자량 202.21
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화학식 C7H14N4O3
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Color White to off-white
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SMILES
O=[N+](N/C(NC)=N/CC1COCC1)[O-]
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Synonyms
MTI-446
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (4)
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Journal Impact Factor
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Most Recent
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J Hazard Mater
Impact of long-term cadmium exposure on insecticidal cross-resistance and biological traits of Brown planthopper Nilaparvata lugens (Hemiptera: Delphacidae). [Abstract]2025 Apr 7:492:138203. PMID: 40209407 -
Insect Biochem Mol Biol
Development of an efficient insecticide substrate and inhibitor screening system of insect P450s using fission yeast. [Abstract]2023 Jun:157:103958. PMID: 37182814 -
Insects
The Transcriptomic Landscape of Molecular Effects after Sublethal Exposure to Dinotefuran on Apis mellifera. [Abstract]2021 Oct 2;12(10):898. PMID: 34680667 -
용액&용해도
DMSO : 66.67 mg/mL (329.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 50 mg/mL (247.27 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 25 mg/mL (123.63 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
순도&문서
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Data Sheet (278 KB)
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SDS (761 KB)
- English - EN (761 KB)
- Français - FR (761 KB)
- Deutsch - DE (761 KB)
- Norwegian - NO (761 KB)
- Español - ES (761 KB)
- Swedish - SV (761 KB)
- Italian - IT (761 KB)
- Portuguese - PT (761 KB)
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Handling Instructions (2659 KB)
References
[1]. Mori K, et al. Interaction of dinotefuran and its analogues with nicotinic acetylcholine receptors of cockroach nerve cords. Pest Manag Sci. 2002 Feb;58(2):190-6. [Content Brief]
[2]. Liu T, et al. Biochemical and genetic toxicity of dinotefuran on earthworms (Eisenia fetida). Chemosphere. 2017 Jun;176:156-164. [Content Brief]
[3]. Tanaka T, et al. Reproductive and neurobehavioral effects of dinotefuran in an F1 -generation toxicity study in mice. Birth Defects Res. 2023 Oct 1;115(16):1534-1555. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 4.9454 mL | 24.7268 mL | 49.4535 mL | 123.6338 mL |
| 5 mM | 0.9891 mL | 4.9454 mL | 9.8907 mL | 24.7268 mL | |
| 10 mM | 0.4945 mL | 2.4727 mL | 4.9454 mL | 12.3634 mL | |
| 15 mM | 0.3297 mL | 1.6485 mL | 3.2969 mL | 8.2423 mL | |
| 20 mM | 0.2473 mL | 1.2363 mL | 2.4727 mL | 6.1817 mL | |
| 25 mM | 0.1978 mL | 0.9891 mL | 1.9781 mL | 4.9454 mL | |
| 30 mM | 0.1648 mL | 0.8242 mL | 1.6485 mL | 4.1211 mL | |
| 40 mM | 0.1236 mL | 0.6182 mL | 1.2363 mL | 3.0908 mL | |
| 50 mM | 0.0989 mL | 0.4945 mL | 0.9891 mL | 2.4727 mL | |
| 60 mM | 0.0824 mL | 0.4121 mL | 0.8242 mL | 2.0606 mL | |
| 80 mM | 0.0618 mL | 0.3091 mL | 0.6182 mL | 1.5454 mL | |
| 100 mM | 0.0495 mL | 0.2473 mL | 0.4945 mL | 1.2363 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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