Isomaltose
Based on 1 Customer Validation
Isomaltose (6-O-α-D-Glucopyranosyl-D-glucose) is a glucose disaccharide. Isomaltose induces G-CSF secretion via heat-induced oxidative polymerization of glucose groups into high-molecular-weight compounds. Isomaltose modulates cecal bacterial cluster structure in mice. Isomaltose exhibits low glycemic index, slow hydrolysis, and prebiotic properties. Isomaltose reduces in vivo Cryptosporidium parvum colonization in neonatal mice. Isomaltose can be used for the research of Cryptosporidium parvum infection.
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- Purity: 98.0%
- CAS No.: 499-40-1
- 화학식: C12H22O11
- 분자량:342.30
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보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Biological Activity
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Human Endogenous Metabolite |
Isomaltose (0.4-250 µg/mL; 24 h cell incubation, varied heating conditions) induces G-CSF secretion in MCE301 intestinal epithelial cells via TLR4 activation, with optimal heating conditions at 150°C for 240 min, 180°C for 60 min, or 200°C for 15-30 min, and dose-dependent activity at 0.4-250 µg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCE301 intestinal epithelial cells
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Concentration:0.4-250 µg/mL (G-CSF induction); 100 µg/mL (TLR inhibition assay); 250 µg/mL (temperature-time optimization)
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Incubation Time:24 h
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Result:Induced G-CSF secretion in a dose-dependent manner at 0.4-250 µg/mL.
Showed no effect at 120°C across 10-240 min.
Induced G-CSF secretion only after 240 min at 150°C.
Increased activity time-dependently up to 60 min (maximal effect) then diminished at 180°C; lost effect after 240 min of heating. Increased activity from 15-30 min then lost effect at 60 min at 200°C.
Had G-CSF secretion-inducing activity significantly inhibited by sparstolonin B (TLR2/TLR4 inhibitor) and TAK-242 (TLR4 inhibitor) at 100 µg/mL.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (7 days old, infant, challenged with Cryptosporidium parvum)[3]
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Dosage:5 g/10 mL solution
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Administration:p.o.; single dose
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Result:Recorded a fecal oocyst score of 1.39, with 8/9 mice positive for fecal oocysts; measured an ileal histology score of 1.22, with 7/9 mice positive for ileal infection; observed marked vacuolation of the small intestinal epithelium 1 day after treatment, which resolved to normal appearance by 3 days after treatment.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 499-40-1
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Appearance Solid
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분자량 342.30
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화학식 C12H22O11
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Color White to off-white
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SMILES
O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)CO
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Synonyms
6-O-α-D-Glucopyranosyl-D-glucose; D-Isomaltose
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
용액&용해도
H2O : 125 mg/mL (365.18 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (146.07 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
순도&문서
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Xu X, et al. Honey isomaltose contributes to the induction of granulocyte-colony stimulating factor (G-CSF) secretion in the intestinal epithelial cells following honey heating. Sci Rep. 2020;10(1):15178. Published 2020 Sep 16. [Content Brief]
[2]. Murakami A, et al. Koji amazake produced by double saccharification contains more isomaltose and modifies the gut microbiota in mice. Front Nutr. 2024 Nov 6;11:1489912. [Content Brief]
[3]. Harp JA, et al. Oral dosing of neonatal mice with sucrose reduces infection with Cryptosporidium parvum. J Parasitol. 1999;85(5):952-955. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.9214 mL | 14.6071 mL | 29.2141 mL | 73.0354 mL |
| 5 mM | 0.5843 mL | 2.9214 mL | 5.8428 mL | 14.6071 mL | |
| 10 mM | 0.2921 mL | 1.4607 mL | 2.9214 mL | 7.3035 mL | |
| 15 mM | 0.1948 mL | 0.9738 mL | 1.9476 mL | 4.8690 mL | |
| 20 mM | 0.1461 mL | 0.7304 mL | 1.4607 mL | 3.6518 mL | |
| 25 mM | 0.1169 mL | 0.5843 mL | 1.1686 mL | 2.9214 mL | |
| 30 mM | 0.0974 mL | 0.4869 mL | 0.9738 mL | 2.4345 mL | |
| 40 mM | 0.0730 mL | 0.3652 mL | 0.7304 mL | 1.8259 mL | |
| 50 mM | 0.0584 mL | 0.2921 mL | 0.5843 mL | 1.4607 mL | |
| 60 mM | 0.0487 mL | 0.2435 mL | 0.4869 mL | 1.2173 mL | |
| 80 mM | 0.0365 mL | 0.1826 mL | 0.3652 mL | 0.9129 mL | |
| 100 mM | 0.0292 mL | 0.1461 mL | 0.2921 mL | 0.7304 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Isomaltose Related Classifications
Cat. No.: HY-N3018
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- Isomaltose
- 499-40-1
- 6-O-α-D-Glucopyranosyl-D-glucose
- D-Isomaltose
- Endogenous Metabolite
- Parasite
- MCE301 intestinal epithelial cells
- G-CSF
- TLR4
- Anaerotignum lactatifermentans
- granulocyte-colony stimulating factor
- Parabacteroides merdae
- Cryptosporidium parvum
- Muribaculum intestinale
- BALB/c mice
- Inhibitor
- inhibitor
- inhibit