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Cat. No.: HY-N2341

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Palmitelaidic acid

(Synonyms: 9-trans-Hexadecenoic acid; trans-Palmitoleic acid)

3 Cited Publications

고객리뷰

Based on 3 publication(s) in Google Scholar

Palmitelaidic acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.4%
CAS No.: 10030-73-6
화학식: C₁₆H₃₀O₂
분자량:254.41

보관:

Solution, -20°C, 2 years

Palmitelaidic acid Chemical Structure

CAS No.: 10030-73-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Protocol
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Palmitelaidic acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.

IC₅₀ & Target^[2]

AMPK

PPARα

Glucokinase

All AMPK Isoforms :

All PPAR Isoforms :

In Vitro

The monounsaturated fatty acid palmitoleate (palmitoleic acid) is one of the most abundant fatty acids in serum and tissues, particularly adipose tissue and liver. Its endogenous production by stearoyl-CoA desaturase 1 gives rise to its cis isoform, cis-palmitoleate. Palmitoleic acid has been correlated with multiple cardiometabolic risk factors, including high blood pressure, total cholesterol, TGs, apoA-I, apoB, and endothelial dysfunction^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Palmitoleic acid promotes a faster uptake of glucose in the body, associated with higher insulin concentration. Palmitoleic acid increases the phosphorylation of AMPK, up-regulates glucokinase and down-regulates SREBP-1. Regarding AMPK downstream, palmitoleic acid increases the production of FGF-21 and stimulates the expression of PPARα^[2]. Palmitoleic acid reduces body weight increase, ameliorates the development of hyperglycemia and hypertriglyceridemia, and improves insulin sensitivity. Furthermore, palmitoleic acid down-regulates mRNA expressions of proinflammatory adipocytokine genes (TNFα and resistin) in white adipose tissue and lipogenic genes (SREBP-1, FAS, and SCD-1) in liver^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 10030-73-6
Appearance Liquid
분자량 254.41
화학식 C₁₆H₃₀O₂
Color Colorless to light yellow
SMILES

CCCCCC/C=C/CCCCCCCC(O)=O
Synonyms

9-trans-Hexadecenoic acid; trans-Palmitoleic acid
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Animals
beef samples
선적

Room temperature in continental US; may vary elsewhere.
보관

Solution, -20°C, 2 years

Publications (3)

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Journal Impact Factor

Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
Nat Commun

2022 Nov 28;13(1):7335. PMID: 36443325

Palmitelaidic acid purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Nov 28;13(1):7335.

Several well-recognized reproductive associated metabolites, such as β-Nicotinamide Adenine Dinucleotide (NAD+), carnitine and glutathione52 were significantly downregulated in APLN treated Sertoli cells, whereas Palmitelaidic Acid was clearly induced upon APLN treatment.

Palmitelaidic acid purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Nov 28;13(1):7335.

Immunoblots of AMPKα1 and p-AMPKα1 in TM4 treated APLN or different concentrations of Palmitelaidic Acid.
J Neurosci Res

Enhanced mitochondrial inhibition by 3,4-dihydroxyphenyl-acetaldehyde (DOPAL)-oligomerized α-synuclein. [Abstract]

2019 Dec;97(12):1689-1705. PMID: 31420910

Protocol

Animal Administration^[2]

Mice: Male C57BL/6J wild type and PPARα-KO mice are fed a high-fat diet or a standard diet for 12 weeks. In the last two weeks, the HF-fed mice are treated daily with oleic acid (300 mg/kg of body weight) or palmitoleic acid (00 mg/kg of body weight) by oral gavage. After 12 weeks, the mice are fasted for 6 h, injected with insulin or PBS vehicle. Blood and liver samples are collected and stored for the further analysis of RNA and protein expression^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Frigolet ME, et al. The Role of the Novel Lipokine Palmitoleic Acid in Health and Disease. [Content Brief]

[2]. de Souza CO, et al. Palmitoleic Acid Improves Metabolic Functions in Fatty Liver by PPARα-Dependent AMPK Activation. J Cell Physiol. 2016 Dec 7. doi: 10.1002/jcp.25715. [Content Brief]

[3]. Yang ZH, et al. Chronic administration of palmitoleic acid reduces insulin resistance and hepatic lipid accumulation in KK-Ay Mice with genetic type 2 diabetes. Lipids Health Dis. 2011 Jul 21;10:120. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Palmitelaidic acid

3 Cited Publications

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Protocol
순도&문서
References

1/16
1/16

Palmitelaidic acid purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Nov 28;13(1):7335.

Customer Validation
Several well-recognized reproductive associated metabolites, such as β-Nicotinamide Adenine Dinucleotide (NAD+), carnitine and glutathione52 were significantly downregulated in APLN treated Sertoli cells, whereas Palmitelaidic Acid was clearly induced upon APLN treatment.
1/16

Palmitelaidic acid purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Nov 28;13(1):7335.

Customer Validation
Immunoblots of AMPKα1 and p-AMPKα1 in TM4 treated APLN or different concentrations of Palmitelaidic Acid.

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Palmitelaidic acid

Publications Citing Use of MedChemExpress (MCE) Palmitelaidic acid

All AMPK Isoforms

All PPAR Isoforms

Biological Activity

Chemical Information

Publications (3)

Protocol

순도&문서

References

Calculators

Help & FAQs

Palmitelaidic acid Related Classifications

HY-N2341 Related Classifications