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Cat. No.: HY-117118A

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AC-90179

AC-90179 is a selective 5-HT2A receptor inverse agonist (K_i = 2.1 nM) and 5-HT2C antagonist, a potential antipsychotic compound.

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CAS No.: 359878-19-6
화학식: C₂₃H₃₁ClN₂O₂
분자량:402.96

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

AC-90179 Chemical Structure

CAS No.: 359878-19-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

AC-90179 is a selective 5-HT2A receptor inverse agonist (K_i = 2.1 nM) and 5-HT2C antagonist, a potential antipsychotic compound^[1].

IC₅₀ & Target

5-HT_2A Receptor

5-HT_2C Receptor

All 5-HT Receptor Isoforms :

In Vivo

AC-90179 (1-10 mg/kg i.p., 30 min) completely reversed the DOI (0.3-3 mg/kg i.p., 15 min)-induced suppression of response rates, whereas at lower doses of AC-90179 (1 mg/kg i.p., 30 min), only partial reversal of DOI-induced inhibition was observed in C57BL/6 mice^[1].
AC-90179(1 or 3 mg/kg s.c.) can attenuate phencyclidine (3 mg/kg i.p., 15 min)-induced hyperactivity of NSA mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 359878-19-6
분자량 402.96
화학식 C₂₃H₃₁ClN₂O₂
SMILES

O=C(N(CC1=CC=C(C)C=C1)C2CCN(C)CC2)CC3=CC=C(OC)C=C3.Cl
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kimberly E. Vanover, et al. Pharmacological Characterization of AC-90179 [2-(4-Methoxyphenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide Hydrochloride]: A Selective Serotonin 2A Receptor Inverse Agonist. Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 943-951

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References

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AC-90179

High-Throughput Bioactive Compound Library

All 5-HT Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

AC-90179 Related Classifications

HY-117118A Related Classifications