Anpirtoline
Anpirtoline (D-16949) is a centrally acting 5-HT1B receptor agonist, with Kis of 28 nM (5-HT1B), 150 nM (5-HT1A) and 1.49 μM (5-HT2). Anpirtoline has serotonergic, antinociceptive, antidepressant-like effects.
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- CAS No.: 98330-05-3
- 화학식: C10H13ClN2S
- 분자량:228.74
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All 5-HT Receptor Isoforms
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Biological Activity
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5-HT1A Receptor |
5-HT1B Receptor |
Chemical Information
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CAS No. 98330-05-3
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분자량 228.74
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화학식 C10H13ClN2S
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SMILES
ClC1=NC(SC2CCNCC2)=CC=C1
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Synonyms
D-16949
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Swedberg MD, et al. D-16949 (anpirtoline): a novel serotonergic (5-HT1B) psychotherapeutic agent assessed by its discriminative effects in the rat. J Pharmacol Exp Ther. 1992 Dec;263(3):1015-22. [Content Brief]
[2]. Chien PY, et al. The dorsal raphe-to-ventral hippocampal projection modulates reactive aggression through 5-HT1B receptors. Eur J Pharmacol. 2024 Oct 15;981:176918. [Content Brief]
[3]. Schlicker E, et al. Anpirtoline, a novel, highly potent 5-HT1B receptor agonist with antinociceptive/antidepressant-like actions in rodents. Br J Pharmacol. 1992 Mar;105(3):732-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anpirtoline Related Classifications
HY-101100A Related Classifications
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