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Cat. No.: HY-181266

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Antimalarial agent 55

Antimalarial agent 55 is an orally potent inhibitor of PfA-M1 and PfA-M17 aminopeptidases from Plasmodium falciparum, with K_i values of 27 nM and 81 nM, respectively. Antimalarial agent 55 exhibits potent nanomolar activity against homologous enzymes from Plasmodium vivax and Plasmodium berghei, with K_i values of 2 nM, 4 nM, 190 nM and 18 nM for Pv-M1, Pb-M1, Pv-M17 and Pb-M17, respectively. Antimalarial agent 55 possesses significant antiplasmodial activity, as well as cross-species inhibitory capacity and broad-spectrum activity that is unaffected by existing drug resistance mechanisms. Antimalarial agent 55 can be used in malaria research.

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화학식: C₁₇H₂₁N₃O₃
분자량:315.37

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Antimalarial agent 55 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Parasite Isoforms :

All Aminopeptidase Isoforms :

CD13
LTA4H

In Vitro

Antimalarial agent 55 (Compound 3k) (72 h) exhibits in vitro killing activity against the Plasmodium falciparum strain Pf3D7, with an EC₅₀ of 31 nM; it also shows potent activity against clinically isolated Plasmodium falciparum strains with different drug resistance mechanisms.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	Clearance (CL)	T_1/2	V_ss	B/P	Bioavailability	C_max	T_max
Mice^[1]	1 mg/kg	i.v.	36.1 mL/min/kg	0.86 h	0.447 L/kg	0.75	/	/	/
Mice^[1]	3 mg/kg	p.o.	/	11 h	/	/	61.8 %	2.04 μM	0.25 h
Mice^[1]	50 mg/kg	p.o.	/	7.2 h	/	/	63.4 %	20 μM	0.25 h

In Vivo

Antimalarial agent 55 (Compound 3k) (50 mg/kg; p.o.; at 2 h, 4 doses) achieves 100% antimalarial activity at 3 days post-infection in Plasmodium berghei-infected Swiss mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Arc:Arc(Swiss) (female, 6-weeks of age, intraperitoneal infection with 2 × 107 Plasmodium berghei ANKA-infected erythrocytes)^[1]
Dosage:

50 mg/kg
Administration:

p.o.; at 2 h, day 1, day 2, and day 3 postinfection
Result:

Achieved 100% antimalarial activity at 3 days post-infection.\nAchieved 83% antimalarial activity at 4 days post-infection.\nAchieved 63% antimalarial activity at 6 days post-infection.

Chemical Information

분자량 315.37
화학식 C₁₇H₂₁N₃O₃
SMILES

CC(C)(C)CC(NC(C1=CC=C2C=CC=NC2=C1)C(NO)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mansouri M, et al. Novel Scaffold Unlocks Potent Cross-Peptidase and Cross-Species Inhibitors as Promising Antimalarial Agents. J Med Chem. 2026;69(2):1358-1386. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
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수량:
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Antimalarial agent 55

All Parasite Isoforms

All Aminopeptidase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Antimalarial agent 55 Related Classifications

HY-181266 Related Classifications