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Cat. No.: HY-186016

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Arg-PEG1-Dasa

Arg-PEG1-Dasa is a mini-PROTAC targeting BCR-ABL. Arg-PEG1-Dasa induces BCR-ABL degradation (EC₅₀ = 0.85 nM) and shows antiproliferative activity in K562 cells (IC₅₀ = 0.36 nM). Arg-PEG1-Dasa can be used for chronic myeloid leukemia research.
(Pink: Bcr-Abl ligand (HY-10181); Blue: Ligands for E3 Ligase ligand (HY-N0455); Black: linker).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 3037776-67-0
화학식: C₃₃H₄₇ClN₁₂O₅S
분자량:759.32

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

Arg-PEG1-Dasa Chemical Structure

CAS No.: 3037776-67-0

사이즈

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재고

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

Arg-PEG1-Dasa is a mini-PROTAC targeting BCR-ABL. Arg-PEG1-Dasa induces BCR-ABL degradation (EC₅₀ = 0.85 nM) and shows antiproliferative activity in K562 cells (IC₅₀ = 0.36 nM). Arg-PEG1-Dasa can be used for chronic myeloid leukemia research^[1]. (Pink: Bcr-Abl ligand (HY-10181); Blue: Ligands for E3 Ligase ligand (HY-N0455); Black: linker).

All PROTACs Isoforms :

All Bcr-Abl Isoforms :

Abl
Bcr-Abl

Chemical Information

CAS No. 3037776-67-0
분자량 759.32
화학식 C₃₃H₄₇ClN₁₂O₅S
SMILES

CC1=NC(NC2=NC=C(C(NC3=C(C=CC=C3Cl)C)=O)S2)=CC(N4CCN(CC4)CCOC(CCOCCNC([C@@H](N)CCCNC(N)=N)=O)=O)=N1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen X, et al. Mighty mini-PROTACs: an emerging class of degraders. Eur J Med Chem. 2026 Jan 5;301:118202. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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Arg-PEG1-Dasa

All PROTACs Isoforms

All Bcr-Abl Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Arg-PEG1-Dasa Related Classifications

HY-186016 Related Classifications