Balomenib
Based on 1 Customer Validation
Balomenib (ZE63-0302) is an orally bioavailable menin-KMT2A interaction inhibitor. Balomenib disrupts menin-KMT2A binding, reverses aberrant HOX gene expression. Balomenib inhibits Meis1 mRNA expression in KMT2A-rearranged acute myeloid leukemia cells. Balomenib can be used for the research of leukemia.
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- Purity: 99.81%
- CAS No.: 2939850-17-4
- 화학식: C33H34F3N7O2
- 분자량:617.66
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
Balomenib inhibits Meis1 mRNA expression in MOLM‑13 cells (KMT2Ar/MLLr AML cell line) in an exposure‑dependent manner, with peak inhibition at Cmax in an ex vivo plasma inhibitory assay (PIA)[1].
Balomenib disrupts the binding of menin to KMT2A to reverse aberrant HOX gene overexpression driven by menin‑KMT2A interaction in KMT2Ar and NPM1c mutant AML cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2939850-17-4
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Appearance Solid
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분자량 617.66
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화학식 C33H34F3N7O2
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Color White to off-white
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SMILES
FC(F)(F)CC1=CC(C(N(C2)CC2(CC3)CCN3CC4=CC=C(N(C(C#N)=C5)C[C@@H]6CNC(CO6)=O)C5=C4C)=NC=N7)=C7C=C1
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Synonyms
ZE63-0302
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : ≥ 100 mg/mL (161.90 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 2.44 mg/mL (3.95 mM; ultrasonic and adjust pH to 3 with 1 M HCl)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (285 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMSO | 1 mM | 1.6190 mL | 8.0951 mL | 16.1901 mL | 40.4753 mL |
| DMSO | 5 mM | 0.3238 mL | 1.6190 mL | 3.2380 mL | 8.0951 mL |
| 10 mM | 0.1619 mL | 0.8095 mL | 1.6190 mL | 4.0475 mL | |
| 15 mM | 0.1079 mL | 0.5397 mL | 1.0793 mL | 2.6984 mL | |
| 20 mM | 0.0810 mL | 0.4048 mL | 0.8095 mL | 2.0238 mL | |
| 25 mM | 0.0648 mL | 0.3238 mL | 0.6476 mL | 1.6190 mL | |
| 30 mM | 0.0540 mL | 0.2698 mL | 0.5397 mL | 1.3492 mL | |
| 40 mM | 0.0405 mL | 0.2024 mL | 0.4048 mL | 1.0119 mL | |
| 50 mM | 0.0324 mL | 0.1619 mL | 0.3238 mL | 0.8095 mL | |
| 60 mM | 0.0270 mL | 0.1349 mL | 0.2698 mL | 0.6746 mL | |
| 80 mM | 0.0202 mL | 0.1012 mL | 0.2024 mL | 0.5059 mL | |
| 100 mM | 0.0162 mL | 0.0810 mL | 0.1619 mL | 0.4048 mL |
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