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Cat. No.: HY-123874

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BMS-952048

BMS-952048 is a positive allosteric modulator of mGluR5 with an EC₅₀ of 10 nM.

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CAS No.: 1375751-32-8
화학식: C₂₁H₁₃F₂N₃O₂
분자량:377.34

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

BMS-952048 Chemical Structure

CAS No.: 1375751-32-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

BMS-952048 is a positive allosteric modulator of mGluR5 with an EC₅₀ of 10 nM^[1].

All mGluR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	>3000 nM Compound: 22; BMS-952048	Agonist activity at human mGluR5A transfected in HEK293 cells assessed as induction of calcium release by FLIPR assay Agonist activity at human mGluR5A transfected in HEK293 cells assessed as induction of calcium release by FLIPR assay	[PMID: 27496211]
HEK293	EC₅₀	10 nM Compound: 22; BMS-952048	Positive allosteric modulation of human mGluR5A transfected in HEK293 cells assessed as potentiation of L-glutamate-induced calcium release incubated for 10 mins by FLIPR assay Positive allosteric modulation of human mGluR5A transfected in HEK293 cells assessed as potentiation of L-glutamate-induced calcium release incubated for 10 mins by FLIPR assay	[PMID: 27496211]

Chemical Information

CAS No. 1375751-32-8
분자량 377.34
화학식 C₂₁H₁₃F₂N₃O₂
SMILES

O=C1O[C@H](C2=CC=C(F)C=C2)[C@@H](C3=CC(C#CC4=NC=CC=C4F)=CN=C3)N1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Huang, H., et al., (2016). Oxazolidinone-based allosteric modulators of mGluR5: Defining molecular switches to create a pharmacological tool box. Bioorganic & medicinal chemistry letters, 26(17), 4165-4169. [Content Brief]

Calculators

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Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

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Concentration _(start) Concentration _(start)

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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BMS-952048

All mGluR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

BMS-952048 Related Classifications

HY-123874 Related Classifications