Buddledin A
Buddledin A is a 5-LOX inhibitor (IC50 = 50.4 μM) and a COX inhibitor (IC50 = 13.7 μM). Buddedin A inhibits arachidonic acid metabolism via the 5-LOX and COX pathways, suppresses fungal growth, and exerts toxic effects on fish. Buddedin A may play an ecological role in protecting plant roots and stem barks from fungal infection. Buddedin A can be used in studies related to fungal infections.
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- CAS No.: 62346-20-7
- 화학식: C17H24O3
- 분자량:276.37
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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5-LOX |
Buddledin A potently inhibits COX activity in activated rat peritoneal leukocytes, with an IC50 value of 13.7 μM[1].
Buddledin A inhibits the activity of 5-LOX in activated rat peritoneal leukocytes, with an IC50 of 50.4 μM[1].
Buddledin A (12.5 mg/mL) inhibits the growth of Epidermophyton floccosum, Trichophyton interdigitale, Fusarium graminearum and Sordaria fimicola, with an MIC of 12.5 mg/mL[2].
Buddledin A (10 mg/m, 25°C, after 5 to 7 days) inhibits the growth of Fusarium solani[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 62346-20-7
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분자량 276.37
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화학식 C17H24O3
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SMILES
O=C(/C(C)=C/CC1)[C@H](OC(C)=O)[C@@]2([H])C(C)(C)C[C@]2([H])C1=C
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Liao YH, et al. Novel and known constituents from Buddleja species and their activity against leukocyte eicosanoid generation. J Nat Prod. 1999;62(9):1241-1245. [Content Brief]
[2]. Houghton PJ, et al. Terpenoids in Buddleja: relevance to chemosystematics, chemical ecology and biological activity. Phytochemistry. 2003;64(2):385-393. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Buddledin A Related Classifications
HY-N19724 Related Classifications
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