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Cat. No.: HY-118558

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Buthiobate

Name: Buthiobate
Brand: MedChemExpress
SKU: HY-118558
Availability: PreOrder

(Synonyms: S-1358)

Buthiobate (S-1358) is a fungicide. Buthiobate is a cytochrome P-450 inhibitor with an IC₅₀ of 0.4 μM. Buthiobate binds to the heme iron of cytochrome P-450 (low-spin state) via its pyridine group, thereby blocking the initial hydroxylation of the 14α-methyl group. Buthiobate is used in research on powdery mildew in agricultural and horticultural crops.

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CAS No.: 51308-54-4
화학식: C₂₁H₂₈N₂S₂
분자량:372.59

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Buthiobate Chemical Structure

CAS No.: 51308-54-4

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Biological Activity

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All Cytochrome P450 Isoforms :

In Vitro

Buthiobate (0.4-10 μM; 30 min) potently inhibits lanosterol 14α-demethylase activity in rat liver microsomes with an IC₅₀ of 0.4 μM, and achieves near-complete inhibition at 10 μM^[1].
Buthiobate (10^-6-10^-4 M; 3 h) potently inhibits C-14 demethylation in ergosterol biosynthesis in cell-free homogenates of Saccharomyces cerevisiae, with the strongest effect observed at 10^-4 M, resulting in accumulation of lanosterol and reduced formation of downstream sterols^[2].
Buthiobate (various concentrations; 36 μM) binds to three distinct low-spin cytochrome P-450 species in rat liver microsomes with K_D values ranging from 0.38 to 13.2 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 51308-54-4
분자량 372.59
화학식 C₂₁H₂₈N₂S₂
SMILES

CCCCS/C(SCC1=CC=C(C=C1)C(C)(C)C)=N\C2=CC=CN=C2
Synonyms

S-1358
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Yoshida Y, et al. Effects of buthiobate, a fungicide, on cytochrome P-450 of rat liver microsomes. Journal of pharmacobio-dynamics. 1985 Jun;8(6):432-9.

[2]. Kato T, et al. Selective inhibition of the demethylation at C-14 in ergosterol biosynthesis by the fungicide, Denmert (S-1358). Agricultural and Biological Chemistry, 1976, 40(12): 2379-2388.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Buthiobate

All Cytochrome P450 Isoforms

Biological Activity

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In Vitro

Chemical Information

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Buthiobate

All Cytochrome P450 Isoforms

Biological Activity

제품 설명

In Vitro

Chemical Information

순도&문서

References

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Buthiobate Related Classifications

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