Cefiderocol
Based on 20 publication(s) in Google Scholar
Cefiderocol (S-649266) is a siderophore cephalosporin which has a potent activity against a broad range of aerobic Gram-negative bacterial species with MIC50s of 2 μg/mL or less.
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- Purity: 99.60%
- CAS No.: 1225208-94-5
- 화학식: C30H34ClN7O10S2
- 분자량:752.21
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보관:
-20°C, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Cefiderocol
More- Drug Resist Updat. 2026 May:86:101377. [Abstract]
- Clin Microbiol Infect. 2023 May;29(5):652.e1-652.e8. [Abstract]
- Bioorg Chem. 2020 Jan;95:103550. [Abstract]
- RSC Adv. 2024 Jan 18;14(5):2905-2917. [Abstract]
- Antibiotics (Basel). 2023 Jul 20;12(7):1212. [Abstract]
- Antimicrob Agents Chemother. 2026 Mar 4;70(3):e0126325. [Abstract]
- Antimicrob Agents Chemother. 2025 Dec 5:e0084225. [Abstract]
- Antimicrob Agents Chemother. 2024 Mar 6;68(3):e0112023. [Abstract]
- Antimicrob Agents Chemother. 2024 Feb 7;68(2):e0133223. [Abstract]
- Front Microbiol. 2022 Jan 3:12:778190. [Abstract]
- J Infect Public Health. 2023 Dec:16 Suppl 1:33-44. [Abstract]
- Sci Rep. 2025 Sep 29;15(1):33616. [Abstract]
- Sci Rep. 2024 Feb 1;14(1):2657. [Abstract]
- Open Forum Infect Dis. 2025 Apr 25;12(5):ofaf250. [Abstract]
- Microbiol Spectr. 2022 Oct 26;10(5):e0109322. [Abstract]
- J Antimicrob Chemother. 2026 Feb 2;81(3):dkag034. [Abstract]
- PLoS One. 2024 Apr 18;19(4):e0298577. [Abstract]
- Microb Drug Resist. 2025 Sep 8. [Abstract]
- Res Sq. 2026 Mar 9.
- Preprints. 2023 Jun 21.
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Biological Activity
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β-lactam |
Cefiderocol (S-649266), a novel parenteral siderophore cephalosporin conjugated with a catechol moiety, has a characteristic antibacterial spectrum with a potent activity against a broad range of aerobic Gram-negative bacterial species, including carbapenem-resistant strains of Enterobacteriaceae and nonfermenting bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii. Cefiderocol has affinity mainly for PBP3 of Enterobacteriaceae and nonfermenting bacteria similar to that of GR20263. A deficiency of the iron transporter PiuA in P. aeruginosa or both CirA and Fiu in Escherichia coli can cause 16-fold increases in cefiderocol MICs, suggesting that these iron transporters contribute to the permeation of cefiderocol across the outer membrane. The deficiency of OmpK35/36 in Klebsiella pneumoniae and the overproduction of efflux pump MexA-MexB-OprM in P. aeruginosa show no significant impact on the activity of cefiderocol[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1225208-94-5
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Appearance Solid
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분자량 752.21
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화학식 C30H34ClN7O10S2
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Color White to off-white
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SMILES
O=C(C(N12)=C(C[N+]3(CCNC(C4=CC=C(O)C(O)=C4Cl)=O)CCCC3)CS[C@]2([H])[C@H](NC(/C(C5=CSC(N)=N5)=N\OC(C)(C(O)=O)C)=O)C1=O)[O-]
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Synonyms
S-649266
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
Publications (20)
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Journal Impact Factor
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Most Recent
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Drug Resist Updat
2026 May:86:101377. PMID: 41702031 -
Clin Microbiol Infect
Performance of discs, sensititre EUMDROXF microplates and MTS gradient strips for the determination of the susceptibility of multidrug resistant Pseudomonas aeruginosa to cefiderocol. [Abstract]2023 May;29(5):652.e1-652.e8. PMID: 36587736 -
Bioorg Chem
Design, synthesis and biological evaluation of novel DNA gyrase inhibitors and their siderophore mimic conjugates. [Abstract]2020 Jan;95:103550. PMID: 31911309 -
RSC Adv
Benzothiazole DNA gyrase inhibitors and their conjugates with siderophore mimics: design, synthesis and evaluation. [Abstract]2024 Jan 18;14(5):2905-2917. PMID: 38239435 -
Antibiotics (Basel)
Comparison of Disk Diffusion, E-Test, and Broth Microdilution Methods for Testing In Vitro Activity of Cefiderocol in Acinetobacter baumannii. [Abstract]2023 Jul 20;12(7):1212. PMID: 37508308
Cefiderocol purchased from MedChemExpress. Usage Cited in: Antibiotics (Basel). 2023 Jul 20;12(7):1212. [Abstract]
Distribution of Cefiderocol MICs determined with the standard BMD method according to the acquired carbapenem-resistance marker(s).
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Antimicrob Agents Chemother
A genomics-informed mechanism-based pharmacokinetic/pharmacodynamic model of cefiderocol and ceftazidime/avibactam against carbapenem-resistant Achromobacter xylosoxidans. [Abstract]2026 Mar 4;70(3):e0126325. PMID: 41586494
Cefiderocol purchased from MedChemExpress. Usage Cited in: Antimicrob Agents Chemother. 2026 Mar 4;70(3):e0126325. [Abstract]
Expected in vitro PD effect with different infusion durations in the Ax114 strain and Ax130 strain. Simulations were performed using body weight-based dosing of Ceftazidime/Avibactam (50/12.5 mg/kg, capped at 2,000/500 mg) and Cefiderocol (60 mg/kg, capped at 2,000 mg) administered every 8 h. Solid lines represent the median predicted bacterial response, and shaded areas indicate the 95% confidence interval based on the MBM simulations.
Cefiderocol purchased from MedChemExpress. Usage Cited in: Antimicrob Agents Chemother. 2026 Mar 4;70(3):e0126325. [Abstract]
CFU reduction (log10 CFU/mL) with Ceftazidime/Avibactam and Cefiderocol as monotherapies (blue) and in combination (red), compared to the growth control (green). Data are shown for Ax114 (small circles) and Ax130 (larger circles with grid), highlighting differential responses across strains and treatments.
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Antimicrob Agents Chemother
Activity of aztreonam-avibactam, cefiderocol, and cefepime-taniborbactam against a global collection of genetically characterized metallo-β-lactamase-producing Enterobacterales. [Abstract]2025 Dec 5:e0084225. PMID: 41347523
Cefiderocol purchased from MedChemExpress. Usage Cited in: Antimicrob Agents Chemother. 2025 Dec 5:e0084225. [Abstract]
Activity of Aztreonam-avibactam, Cefiderocol, Cefepime-taniborbactam, Tigecycline, and Colistin against MBL-producing Enterobacterales stratified by country, organism, and MBL type.
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Antimicrob Agents Chemother
Meropenem-ANT3310, a unique β-lactam-β-lactamase inhibitor combination with expanded antibacterial spectrum against Gram-negative pathogens including carbapenem-resistant Acinetobacter baumannii. [Abstract]2024 Mar 6;68(3):e0112023. PMID: 38289044 -
Antimicrob Agents Chemother
2024 Feb 7;68(2):e0133223. PMID: 38174924
Cefiderocol purchased from MedChemExpress. Usage Cited in: Antimicrob Agents Chemother. 2024 Feb 7;68(2):e0133223. [Abstract]
Minimum inhibitory concentrations (MICs) of different β-lactams against E. coli DH10B strains harboring the pHSG298 blaNDM-1(K224X) gene. The heat map represents the doubling dilution changes in the MIC values of the K224X variants compared with that of the NDM-1 wild type. The results shown are the mode of three biological replicates. FEP, cefepime; CAZ, ceftazidime; IMI, imipenem; TBPM, tebipenem; FDC, Cefiderocol; WT, wild type.
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Front Microbiol
Proteomic and Transcriptomic Analyses Indicate Reduced Biofilm-Forming Abilities in Cefiderocol-Resistant Klebsiella pneumoniae. [Abstract]2022 Jan 3:12:778190. PMID: 35046911 -
J Infect Public Health
High efficacy and enhanced synergistic activity of the novel siderophore-cephalosporin cefiderocol against multidrug-resistant and extensively drug-resistant Klebsiella pneumoniae from inpatients attending a single hospital in the United Arab Emirates. [Abstract]2023 Dec:16 Suppl 1:33-44. PMID: 37953111 -
Sci Rep
Sporadic cefiderocol resistance in Escherichia coli from the United Arab Emirates involves multifactorial mechanisms reversible by novel beta-lactamase inhibitors. [Abstract]2025 Sep 29;15(1):33616. PMID: 41023121 -
Sci Rep
Optimized preparation pipeline for emergency phage therapy against Pseudomonas aeruginosa at Yale University. [Abstract]2024 Feb 1;14(1):2657. PMID: 38302552 -
Open Forum Infect Dis
Aztreonam-avibactam Demonstrates Potent Activity Against Carbapenem-resistant Enterobacterales Collected From US Medical Centers Over a 6-year Period (2017-2022). [Abstract]2025 Apr 25;12(5):ofaf250. PMID: 40365080 -
Microbiol Spectr
Proteomic Investigation of the Antibacterial Mechanism of Cefiderocol against Escherichia coli. [Abstract]2022 Oct 26;10(5):e0109322. PMID: 35980225 -
J Antimicrob Chemother
Comparative activity of established versus new-generation β-lactams against AmpC-hyperproducing clinical isolates of Enterobacter cloacae complex and Klebsiella aerogenes: a multicentre study. [Abstract]2026 Feb 2;81(3):dkag034. PMID: 41648989 -
PLoS One
In vitro activity of ceftazidime/avibactam, cefiderocol, meropenem/vaborbactam and imipenem/relebactam against clinical strains of the Stenotrophomonas maltophilia complex. [Abstract]2024 Apr 18;19(4):e0298577. PMID: 38635685 -
Microb Drug Resist
2025 Sep 8. PMID: 40916806 -
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용액&용해도
DMSO : 100 mg/mL (132.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 1.06 mg/mL (1.41 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (2.77 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (2.77 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * The compound is unstable in solutions, freshly prepared is recommended.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Protocol
For the determination of cefiderocol MIC, iron-depleted cation-adjusted Mueller-Hinton broth (ID-CAMHB) is prepared, except for the cases that are required to determine MICs under specific conditions. The quality control MIC ranges of cefiderocol are 0.06 to 0.5 μg/mL for both E. coli ATCC 25922 and P. aeruginosa ATCC 27853. For anaerobic bacteria, brucella agar supplemented with hemin, vitamin K1, and laked sheep blood is used[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
순도&문서
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Data Sheet (295 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.3294 mL | 6.6471 mL | 13.2942 mL | 33.2354 mL |
| DMSO | 5 mM | 0.2659 mL | 1.3294 mL | 2.6588 mL | 6.6471 mL |
| 10 mM | 0.1329 mL | 0.6647 mL | 1.3294 mL | 3.3235 mL | |
| 15 mM | 0.0886 mL | 0.4431 mL | 0.8863 mL | 2.2157 mL | |
| 20 mM | 0.0665 mL | 0.3324 mL | 0.6647 mL | 1.6618 mL | |
| 25 mM | 0.0532 mL | 0.2659 mL | 0.5318 mL | 1.3294 mL | |
| 30 mM | 0.0443 mL | 0.2216 mL | 0.4431 mL | 1.1078 mL | |
| 40 mM | 0.0332 mL | 0.1662 mL | 0.3324 mL | 0.8309 mL | |
| 50 mM | 0.0266 mL | 0.1329 mL | 0.2659 mL | 0.6647 mL | |
| 60 mM | 0.0222 mL | 0.1108 mL | 0.2216 mL | 0.5539 mL | |
| 80 mM | 0.0166 mL | 0.0831 mL | 0.1662 mL | 0.4154 mL | |
| 100 mM | 0.0133 mL | 0.0665 mL | 0.1329 mL | 0.3324 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Cefiderocol Related Classifications
HY-17628 Related Classifications
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