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Cat. No.: HY-N12151

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Chaparrinone

Name: Chaparrinone
Brand: MedChemExpress
SKU: HY-N12151
Price: 520.00 USD
Availability: InStock
Rating: 5 (1 reviews)

Chaparrinone is a quassinoid that can be isolated from the root of Eurycoma harmandiana. Chaparrinone has antimalarial and cytotoxic activities against Plasmodium falciparum and P-388 cells (IC₅₀: 0.037 and 0.34 μg/mL respectively).

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CAS No.: 22611-34-3
화학식: C₂₀H₂₆O₇
분자량:378.42

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Chaparrinone Chemical Structure

CAS No.: 22611-34-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
Protocol (2)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BT-549	IC₅₀	0.8 μg/mL Compound: chaparrinone	Cytotoxicity against human BT549 cells after 2 to 7 days by neutral red assay Cytotoxicity against human BT549 cells after 2 to 7 days by neutral red assay	[PMID: 8984156]
Hep 3B2	IC₅₀	2.17 μM Compound: 4	Cytotoxicity against human Hep3B cells measured after 48 hrs by MTT assay Cytotoxicity against human Hep3B cells measured after 48 hrs by MTT assay	[PMID: 23290052]
HepG2	IC₅₀	>50 μM Compound: 4	Cytotoxicity against human adriamycin-resistant HepG2 cells measured after 48 hrs by MTT assay Cytotoxicity against human adriamycin-resistant HepG2 cells measured after 48 hrs by MTT assay	[PMID: 23290052]
HepG2	IC₅₀	1.2 μM Compound: 4	Cytotoxicity against human HepG2 cells measured after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells measured after 48 hrs by MTT assay	[PMID: 23290052]
HL-60	EC₅₀	2.4 μM Compound: 26	Induction of cell differentiation in human HL60 cells assessed as superoxide anion production after 4 days by NBT reduction assay Induction of cell differentiation in human HL60 cells assessed as superoxide anion production after 4 days by NBT reduction assay	[PMID: 11754601]
HL-60	IC₅₀	1.2 μM Compound: 26	Antiproliferative activity against human HL60 cells assessed as inhibition of [3H]thymidine incorporation after 4 days by liquid scintillation counter Antiproliferative activity against human HL60 cells assessed as inhibition of [3H]thymidine incorporation after 4 days by liquid scintillation counter	[PMID: 11754601]
HL-60	IC₅₀	5 μM Compound: 26	Cytotoxicity against human HL60 cells assessed as loss of membrane integrity after 4 days by trypan blue exclusion assay Cytotoxicity against human HL60 cells assessed as loss of membrane integrity after 4 days by trypan blue exclusion assay	[PMID: 11754601]
K562	IC₅₀	1.8 μg/mL Compound: chaparrinone	Cytotoxicity against human K562 cells after 2 to 7 days by neutral red assay Cytotoxicity against human K562 cells after 2 to 7 days by neutral red assay	[PMID: 8984156]
KB	ED₅₀	0.025 μg/mL Compound: 2, NSC-288754	Cytotoxicity against human KB cells by NCI method Cytotoxicity against human KB cells by NCI method	[PMID: 6875576]
KB	IC₅₀	1.2 μg/mL Compound: chaparrinone	Cytotoxicity against human KB cells after 2 to 7 days by neutral red assay Cytotoxicity against human KB cells after 2 to 7 days by neutral red assay	[PMID: 8984156]
P388	IC₅₀	0.92 μg/mL Compound: 6	Cytotoxicity against mouse P388 cells after 3 days by MTT assay Cytotoxicity against mouse P388 cells after 3 days by MTT assay	[PMID: 9644063]
SK-OV-3	IC₅₀	0.5 μg/mL Compound: chaparrinone	Cytotoxicity against human SKOV3 cells after 2 to 7 days by neutral red assay Cytotoxicity against human SKOV3 cells after 2 to 7 days by neutral red assay	[PMID: 8984156]
Vero	IC₅₀	1.5 μg/mL Compound: chaparrinone	Cytotoxicity against african green monkey Vero cells after 2 to 7 days by neutral red assay Cytotoxicity against african green monkey Vero cells after 2 to 7 days by neutral red assay	[PMID: 8984156]

Chemical Information

CAS No. 22611-34-3
분자량 378.42
화학식 C₂₀H₂₆O₇
SMILES

C[C@@]12[C@]3([H])[C@@]45[C@@](OC(C[C@@]4([H])[C@H]([C@H]([C@@]3(OC5)O)O)C)=O)([H])C[C@@]1([H])C(C)=CC([C@H]2O)=O
Structure Classification
- Others
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocol

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kanchanapoom T, et al. Quassinoids from Eurycoma harmandiana. Phytochemistry. 2001 Aug;57(8):1205-8. [Content Brief]

[2]. François G, et al. Antimalarial and cytotoxic potential of four quassinoids from Hannoa chlorantha and Hannoa klaineana, and their structure-activity relationships. Int J Parasitol. 1998 Apr;28(4):635-40. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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