CRS3123
Based on 1 publication(s) in Google Scholar
CRS3123 (REP-3123) is an orally active antibacterial agent that targets methionyl-tRNA synthetase (MetRS). CRS3123 competitively displaces methionine from the active site of MetRS, preventing tRNA charging and protein synthesis, and exhibits greater selectivity for C. difficile MetRS than for human MetRS and Gram-negative bacterial MetRS. CRS3123 can be used in research on Clostridioides difficile infection and vancomycin-resistant enterococcal infection.
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- Purity : 99.37%
- CAS No.: 1013915-71-3
- 화학식: C19H19Br2N3O2S
- 분자량:513.25
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) CRS3123
MoreAll Antibiotic Isoforms
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Biological Activity
제품 설명
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MetRS |
In Vitro
CRS3123 (MIC <0.007-0.031 μg/mL) shows MIC <0.007 μg/mL against most enterococci isolates, including VRE, except E. faecalis HM-335 (0.031 μg/mL)[1].
CRS3123 (5-10× MIC; 24 h) is bacteriostatic against E. faecium NR-31909[1].
CRS3123 (10 days) maintains low resistance development in E. faecalis ATCC 29212 and E. faecium NR-31909 over 10 serial passages, with only 4-16-fold MIC increases[1].
CRS3123 (0.5-1 μg/mL) inhibits C. difficile, including B1/NAP1/027 strains, with an MIC90 of 1 μg/mL[2].
CRS3123 inhibits C. difficile toxin production[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Vero cells (monkey kidney epithelial cells)
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Concentration:16 µg/mL (no toxicity); 32 µg/mL (20% cytotoxicity)
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Incubation Time:24 h; 4 h (MTS/PMS)
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Result:Demonstrated no toxicity up to 16 µg/mL but exhibited 20% cytotoxicity at 32 µg/mL, indicating mild toxicity at this concentration.
Based on the IC50-to-MIC50 comparison, CRS3123 had a ratio of >4571.
Chemical Information
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CAS No. 1013915-71-3
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Appearance Solid
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분자량 513.25
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화학식 C19H19Br2N3O2S
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Color Off-white to light yellow
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SMILES
BrC1=C(OCC2)C([C@@H]2NCCCNC3=CC(C(SC=C4)=C4N3)=O)=CC(Br)=C1
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Synonyms
REP-3123
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Expert Opin Investig Drugs
2025 Nov;34(11):869-885. PMID: 41117146
용액&용해도
In Vitro:
DMSO : 100 mg/mL (194.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (297 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.9484 mL | 9.7418 mL | 19.4837 mL | 48.7092 mL |
| 5 mM | 0.3897 mL | 1.9484 mL | 3.8967 mL | 9.7418 mL | |
| 10 mM | 0.1948 mL | 0.9742 mL | 1.9484 mL | 4.8709 mL | |
| 15 mM | 0.1299 mL | 0.6495 mL | 1.2989 mL | 3.2473 mL | |
| 20 mM | 0.0974 mL | 0.4871 mL | 0.9742 mL | 2.4355 mL | |
| 25 mM | 0.0779 mL | 0.3897 mL | 0.7793 mL | 1.9484 mL | |
| 30 mM | 0.0649 mL | 0.3247 mL | 0.6495 mL | 1.6236 mL | |
| 40 mM | 0.0487 mL | 0.2435 mL | 0.4871 mL | 1.2177 mL | |
| 50 mM | 0.0390 mL | 0.1948 mL | 0.3897 mL | 0.9742 mL | |
| 60 mM | 0.0325 mL | 0.1624 mL | 0.3247 mL | 0.8118 mL | |
| 80 mM | 0.0244 mL | 0.1218 mL | 0.2435 mL | 0.6089 mL | |
| 100 mM | 0.0195 mL | 0.0974 mL | 0.1948 mL | 0.4871 mL |
CRS3123 Related Classifications
HY-18324 Related Classifications
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Keywords
- CRS3123
- 1013915-71-3
- REP-3123
- CRS 3123
- CRS-3123
- REP3123
- REP 3123
- Antibiotic
- Bacterial
- Clostridioides difficile infection
- Enterococcus faecium
- Staphylococcus aureus
- Streptococcus pyogenes
- bacteriostatic
- methionyl-tRNA synthetase
- protein synthesis
- sporulation
- toxin production
- vancomycin-resistant enterococci infection
- Inhibitor
- inhibitor
- inhibit