DCG-IV
Based on 1 Customer Validation
DCG-IV is a potent agonist of group II mGluRs with EC50s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC50: mGlu1R/5R=389/630 μM) and III receptors (IC50: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.9%
- CAS No.: 147782-19-2
- 화학식: C7H9NO6
- 분자량:203.15
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
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mGluR2R 0.35 μM (EC50) |
mGluR3R 0.09 μM (EC50) |
mGluR1R 389 μM (IC50) |
mGluR5 630 μM (IC50) |
mGluR4R 22.5 μM (IC50) |
mGluR6 39.6 μM (IC50) |
mGluR7 40.1 μM (IC50) |
mGluR8 32 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| HEK293 | EC50 |
45 nM
Compound: DCG-IV
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Agonist activity at rat mGlu2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 1 hr by fluorescence microplate reader
Agonist activity at rat mGlu2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 1 hr by fluorescence microplate reader
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[PMID: 20218620] |
| HEK293 | IC50 |
389 μM
Compound: 19
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Inhibitory activity against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells.
Inhibitory activity against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells.
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[PMID: 10229625] |
DCG-IV is also an NMDA receptor agonist in the rat cortical slice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male ICR mice weighing about 40 g (PCP-induced locomotor activity)[4]
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Dosage:10, 5, or 1 mg/kg
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Administration:I.p.
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Result:Reduced spontaneous activities of the animals at 10 or 5 mg/kg.
Chemical Information
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CAS No. 147782-19-2
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Appearance Solid
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분자량 203.15
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화학식 C7H9NO6
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Color White to off-white
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SMILES
O=C([C@H]1[C@H](C(O)=O)C1[C@H](N)C(O)=O)O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
H2O : ≥ 20 mg/mL (98.45 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Brabet I, et al. Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all clonedmetabotropic glutamate receptor subtypes. Neuropharmacology. 1998 Aug;37(8):1043-51. [Content Brief]
[2]. Bertrand HO, et al. Common and selective molecular determinants involved in metabotopic glutamate receptoragonist activity. J Med Chem. 2002 Jul 18;45(15):3171-83. [Content Brief]
[3]. Uyama Y, et al. DCG-IV, a potent metabotropic glutamate receptor agonist, as an NMDA receptor agonist in the rat cortical slice. Brain Res. 1997 Mar 28;752(1-2):327-30. [Content Brief]
[4]. Tomita N, et al. The effects of DCG-IV and L-CCG-1 upon phencyclidine (PCP)-induced locomotion and behavioral changes in mice. Ann N Y Acad Sci. 2000 Sep;914:284-91. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.9225 mL | 24.6124 mL | 49.2247 mL | 123.0618 mL |
| 5 mM | 0.9845 mL | 4.9225 mL | 9.8449 mL | 24.6124 mL | |
| 10 mM | 0.4922 mL | 2.4612 mL | 4.9225 mL | 12.3062 mL | |
| 15 mM | 0.3282 mL | 1.6408 mL | 3.2816 mL | 8.2041 mL | |
| 20 mM | 0.2461 mL | 1.2306 mL | 2.4612 mL | 6.1531 mL | |
| 25 mM | 0.1969 mL | 0.9845 mL | 1.9690 mL | 4.9225 mL | |
| 30 mM | 0.1641 mL | 0.8204 mL | 1.6408 mL | 4.1021 mL | |
| 40 mM | 0.1231 mL | 0.6153 mL | 1.2306 mL | 3.0765 mL | |
| 50 mM | 0.0984 mL | 0.4922 mL | 0.9845 mL | 2.4612 mL | |
| 60 mM | 0.0820 mL | 0.4102 mL | 0.8204 mL | 2.0510 mL | |
| 80 mM | 0.0615 mL | 0.3077 mL | 0.6153 mL | 1.5383 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
DCG-IV Related Classifications
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