DS2
Based on 1 Customer Validation
DS2 is a selective positive allosteric modulator of δ-GABAA receptor. DS2 selectively potentiates GABA responses mediated by α4β3δ receptor. DS2 does not enhance activity at α4β3γ2 and α1β3γ2 receptors. DS2 relieves pain and has the potential for sleep disorders research.
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- Purity: 99.94%
- CAS No.: 374084-31-8
- 화학식: C18H12ClN3OS
- 분자량:353.83
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보관:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 374084-31-8
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Appearance Solid
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분자량 353.83
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화학식 C18H12ClN3OS
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Color Off-white to light brown
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SMILES
O=C(NC1=C(C2=CC=CS2)N=C3C=CC=CN31)C4=CC=C(Cl)C=C4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
용액&용해도
DMSO : 125 mg/mL (353.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8262 mL | 14.1311 mL | 28.2622 mL | 70.6554 mL |
| 5 mM | 0.5652 mL | 2.8262 mL | 5.6524 mL | 14.1311 mL | |
| 10 mM | 0.2826 mL | 1.4131 mL | 2.8262 mL | 7.0655 mL | |
| 15 mM | 0.1884 mL | 0.9421 mL | 1.8841 mL | 4.7104 mL | |
| 20 mM | 0.1413 mL | 0.7066 mL | 1.4131 mL | 3.5328 mL | |
| 25 mM | 0.1130 mL | 0.5652 mL | 1.1305 mL | 2.8262 mL | |
| 30 mM | 0.0942 mL | 0.4710 mL | 0.9421 mL | 2.3552 mL | |
| 40 mM | 0.0707 mL | 0.3533 mL | 0.7066 mL | 1.7664 mL | |
| 50 mM | 0.0565 mL | 0.2826 mL | 0.5652 mL | 1.4131 mL | |
| 60 mM | 0.0471 mL | 0.2355 mL | 0.4710 mL | 1.1776 mL | |
| 80 mM | 0.0353 mL | 0.1766 mL | 0.3533 mL | 0.8832 mL | |
| 100 mM | 0.0283 mL | 0.1413 mL | 0.2826 mL | 0.7066 mL |
DS2 Related Classifications
HY-103520 Related Classifications
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