Exatecan Intermediate 6
Based on 1 Customer Validation
Exatecan Intermediate 6 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 6 can be used to synthesize Antibody-Drug Conjugates (ADCs).
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- Purity: 99.45%
- CAS No.: 143655-58-7
- 화학식: C13H14FNO2
- 분자량:235.26
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
All Topoisomerase Isoforms
More
Biological Activity
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Camptothecins |
Exatecan (DX-8951) is a?DNA?topoisomerase?I?inhibitor.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 143655-58-7
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Appearance Solid
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분자량 235.26
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화학식 C13H14FNO2
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Color Off-white to light yellow
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SMILES
CC(NC(C=C(F)C(C)=C1CCC2)=C1C2=O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 25 mg/mL (106.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.2507 mL | 21.2533 mL | 42.5065 mL | 106.2663 mL |
| 5 mM | 0.8501 mL | 4.2507 mL | 8.5013 mL | 21.2533 mL | |
| 10 mM | 0.4251 mL | 2.1253 mL | 4.2507 mL | 10.6266 mL | |
| 15 mM | 0.2834 mL | 1.4169 mL | 2.8338 mL | 7.0844 mL | |
| 20 mM | 0.2125 mL | 1.0627 mL | 2.1253 mL | 5.3133 mL | |
| 25 mM | 0.1700 mL | 0.8501 mL | 1.7003 mL | 4.2507 mL | |
| 30 mM | 0.1417 mL | 0.7084 mL | 1.4169 mL | 3.5422 mL | |
| 40 mM | 0.1063 mL | 0.5313 mL | 1.0627 mL | 2.6567 mL | |
| 50 mM | 0.0850 mL | 0.4251 mL | 0.8501 mL | 2.1253 mL | |
| 60 mM | 0.0708 mL | 0.3542 mL | 0.7084 mL | 1.7711 mL | |
| 80 mM | 0.0531 mL | 0.2657 mL | 0.5313 mL | 1.3283 mL | |
| 100 mM | 0.0425 mL | 0.2125 mL | 0.4251 mL | 1.0627 mL |
Exatecan Intermediate 6 Related Classifications
HY-44369 Related Classifications
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