country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-172934

Copy Link Print Information

FGT-4

FGT-4 is a FR-β-targeted chimeric molecule. FGT-4 acts as a TLR7 agonist. FGT-4 binds to FR-β to enable delivery to tumor-associated macrophages and myeloid-derived suppressor cells. FGT-4 promotes the secretion of iNOS (associated with M1 macrophages) and the pro-inflammatory cytokine IL-6, and enhances the proliferation of cytotoxic CD8+ T cells. FGT-4 can be used for the research of breast cancer.
(Pink: TLR7 ligand (HY-103698); Blue: FR-β ligand (HY-172935); Black: linker (HY-172936)).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₅₀H₅₇N₁₁O₉S₂
분자량:1020.19

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

FGT-4 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

FGT-4 is a FR-β-targeted chimeric molecule. FGT-4 acts as a TLR7 agonist. FGT-4 binds to FR-β to enable delivery to tumor-associated macrophages and myeloid-derived suppressor cells. FGT-4 promotes the secretion of iNOS (associated with M1 macrophages) and the pro-inflammatory cytokine IL-6, and enhances the proliferation of cytotoxic CD8+ T cells. FGT-4 can be used for the research of breast cancer^[1]. (Pink: TLR7 ligand (HY-103698); Blue: FR-β ligand (HY-172935); Black: linker (HY-172936)).

IC₅₀ & Target^[1]

FR-β

TLR7

IL-6

iNOS

All Toll-like Receptor (TLR) Isoforms :

All NO Synthase Isoforms :

All Interleukin Related Isoforms :

In Vitro

FGT-4 (24 h) exhibits minimal cytotoxicity to 4T1 breast cancer cells and HUVEC cells across a broad concentration range^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

FGT-4 (1 mg/kg; i.v.; daily; 14 days) inhibits 4T1 tumor growth, reprograms tumor-associated macrophages to a pro-inflammatory phenotype, reshapes the tumor immune microenvironment, extends mouse survival to 35 days, and exhibits no apparent systemic toxicity^[1].
FGT-4 (20 μg; s.c.; single dose) does not induce elevated pro-inflammatory cytokine levels in healthy mice, demonstrating improved safety compared to free IMDQ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (female, 6 weeks old, orthotopic 4T1 tumor model, fed 2-week folate-deficient diet)^[1]
Dosage:

1 mg/kg
Administration:

i.v.; daily; 14 days
Result:

Reduced tumor growth compared to control group, with final tumor weights lower than control.
Increased the M1/M2 macrophage ratio in tumor tissues.
Decreased the proportion of Ly6C⁺ and Ly6G⁺ myeloid-derived suppressor cells within CD45⁺ cells.
Upregulated the percentage of CD8⁺ T cells in tumors.
Extended mouse survival to 35 days.
Caused no significant changes in mouse body weight during treatment.
Detected no pathological alterations in heart, liver, spleen, or kidney tissues.

Animal Model:

BALB/c (female, 6 weeks old)^[1]
Dosage:

20 μg
Administration:

s.c.; single dose
Result:

Did not trigger increased plasma levels of TNF-α or IL-6.

Chemical Information

분자량 1020.19
화학식 C₅₀H₅₇N₁₁O₉S₂
SMILES

NC(NC1=O)=NC2=C1C=C(CCCCC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CSSCCOC(NCC4=CC=C(CN5C6=C7C=CC=CC7=NC(N)=C6N=C5CCCC)C=C4)=O)=O)=O)N2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Guo L, et al. Design and Synthesis of FR-β Targeting Chimeric Molecules for Reprogramming Tumor-Associated Macrophages Using 6-Substituted Pyrrolo[2,3-d]pyrimidines as Targeting Ligands. J Med Chem. 2025 Apr 24;68(8):8295-8309. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

FGT-4

All Toll-like Receptor (TLR) Isoforms

All NO Synthase Isoforms

All Interleukin Related Isoforms