IL11 - interleukin 11 Gene
Also Known as AGIF; IL-11
Species: Homo sapiens
About IL11
This gene has 4 transcripts (splice variants), 216 orthologues and is associated with 1 phenotype. Biased expression in endometrium (RPKM 2.0), appendix (RPKM 1.5) and 8 other tissues.
Summary
The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
IL11 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_000641.4 | NP_000632.1 | interleukin-11 isoform 1 precursor |
| NM_001267718.2 | NP_001254647.1 | interleukin-11 isoform 2 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables cytokine activity |
IDA
IDA: Inferred from direct assay
|
33397952 | GOA |
| enables growth factor activity |
IDA
IDA: Inferred from direct assay
|
2145578 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16189514 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| is active in extracellular space |
IDA
IDA: Inferred from direct assay
|
33397952 | GOA |
IL11 Protein Structure
IL11: Interleukin 11 (1 - 199)
- 0
- 100
- 199 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
interleukin-11 |
|
IL11 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
IL11 | P20809 | MAGEA11 | Homo sapiens | P43364 | 32296183 | |
|
Intra
|
IL11 | P20809 | MAGEA11 | Homo sapiens | P43364 | 16189514 | |
|
Intra
|
IL11 | P20809 | MAGEA11 | Homo sapiens | P43364 | 32296183 | |
|
Intra
|
IL11 | P20809 | MAGEA11 | Homo sapiens | P43364 | 32296183 | |
|
Intra
|
IL11 | P20809 | S100P | Homo sapiens | P25815 | 26551460 | |
|
Intra
|
IL11 | P20809 | S100P | Homo sapiens | P25815 | 26551460 | |
|
Intra
|
IL11 | P20809 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 | |
|
Intra
|
IL11 | P20809 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 | |
|
Intra
|
IL11 | P20809 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 |
Recombinant IL11 Proteins
| Cat. No. | 상품명 | Accession | Purity |
|---|---|---|---|
| HY-P7031 | IL-11 Protein, Human | P20809-1 (P22-L199) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P7031A | IL-11 Protein, Human (CHO) | P20809-1 (P22-L199) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70425 | IL-11 Protein, Human (P.pastoris) | P20809-1 (G23-L199) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P700098AF | Animal-Free IL-11 Protein, Human (His) | P20809 (P22-L199) | ≥ 95%, as determined by reducing SDS-PAGE. |
IL11 Antibodies
| Cat. No. | 상품명 | 신청 | Reactivity |
|---|---|---|---|
| HY-P811300 | IL-11 Antibody | WB, IHC-P, ICC/IF | Human, Mouse, Rat |
| HY-P85220 | IL-11 Antibody (YA4912) | WB, ICC/IF, IP, ELISA, IF-Tissue | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Hemorrhagic Cystitis |
|
|
| Plasmacytoma |
|
|
| Mucositis |
|
|
| Thrombocytosis |
|
|
| Acquired Thrombocytopenia |
|
|
| Giant Papillary Conjunctivitis |
|
|
| Periostitis |
|
|
| Thrombocytopenia |
|
|
| Acute Megakaryocytic Leukemia |
|
|
| Neutropenia |
|
|
| Aplastic Anemia |
|
|
| Bronchiolitis |
|
|
| Essential Thrombocythemia |
|
|
| Thrombocytopenic Purpura, Autoimmune |
|
|
| Osteitis Fibrosa |
|
|
| Langerhans Cell Histiocytosis |
|
|
| Osteoporosis |
|
|
| Allergic Disease |
|
|
| Bone Disease |
|
|
| Iron Deficiency Anemia |
|
|
| Hyper Ige Recurrent Infection Syndrome 4 |
|
|
| Inflammatory Bowel Disease |
|
|
| Colitis |
|
|
| Von Willebrand'S Disease |
|
|
| Myelodysplastic Syndrome |
|
|
| Polycythemia Vera |
|
|
| Osteogenic Sarcoma |
|
|
| Rheumatoid Arthritis |
|
|
| Epilepsy, Familial Temporal Lobe, 2 |
|
|
| Psoriasis |
|
|
| Hepatocellular Carcinoma |
|
|
| Hypertelorism, Microtia, Facial Clefting Syndrome |
|
|
| Myeloma, Multiple |
|
|
| Myeloproliferative Neoplasm |
|
|
| Hematologic Cancer |
|
|
| Submucous Uterine Fibroid |
|
|
| Asthma |
|
|
| Blood Platelet Disease |
|
|
| Sodoku Disease |
|
|
| Esophageal Tuberculosis |
|
|
| Leukemia, Chronic Myeloid |
|
|
| Breast Cancer |
|
|
| Crisponi/Cold-Induced Sweating Syndrome 2 |
|
|
| Ovarian Cancer |
|
|
| Deficiency Anemia |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | IL11 | MGD | MGI:107613 |
| Felis catus | IL11 | VGNC | VGNC:67754 |
| Rattus norvegicus | IL11 | RGD | RGD:621475 |
| Bos taurus | IL11 | VGNC | VGNC:30108 |
| Canis familiaris | IL11 | VGNC | VGNC:41930 |
| Others | IL11 | NCBI |