UCHL5 - ubiquitin C-terminal hydrolase L5 Gene

Also Known as UCH37; CGI-70; INO80R; UCH-L5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51377

About UCHL5

Cytogenetic location: 1q31.2 Genomic coordinates (GRCh38): 1:193,012,254-193,060,076 (from NCBI)

This gene has 13 transcripts (splice variants), 213 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 5.2), esophagus (RPKM 3.6) and 25 other tissues.

Summary

Enables endopeptidase inhibitor activity; Proteasome binding activity; and thiol-dependent Deubiquitinase. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of smoothened signaling pathway; and protein deubiquitination. Located in cytosol; nucleolus; and nucleoplasm. Colocalizes with Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022]

UCHL5 Products (17)

mRNA Protein Name
NM_001199261.3 NP_001186190.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 2
NM_001199262.3 NP_001186191.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 3
NM_001199263.3 NP_001186192.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 4
NM_001350840.2 NP_001337769.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 5
NM_001350841.2 NP_001337770.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 6
NM_001350842.2 NP_001337771.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 7
NM_001350843.2 NP_001337772.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 8
NM_001350844.2 NP_001337773.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 9
NM_001350845.2 NP_001337774.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 10
NM_001350846.2 NP_001337775.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 11
NM_001350847.2 NP_001337776.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 12
NM_001350848.2 NP_001337777.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 13
NM_001350849.2 NP_001337778.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 13
NM_001350850.2 NP_001337779.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 14
NM_001350851.2 NP_001337780.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 14
NM_001350852.2 NP_001337781.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 15
NM_015984.5 NP_057068.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
18922472 GOA
enables cysteine-type deubiquitinase activity IMP
IMP: Inferred from mutant phenotype
28992318 GOA
enables endopeptidase inhibitor activity IMP
IMP: Inferred from mutant phenotype
18162577 GOA
enables proteasome binding IDA
IDA: Inferred from direct assay
18162577 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11163772 GOA
Biological Process GO Annotation Evidence References Source
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
21303910 GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
23770237 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
27641337 GOA
involved in positive regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
28992318 GOA
involved in protein deubiquitination IDA
IDA: Inferred from direct assay
18922472 GOA
involved in regulation of DNA replication IMP
IMP: Inferred from mutant phenotype
25016522 GOA
involved in regulation of DNA strand elongation IMP
IMP: Inferred from mutant phenotype
25016522 GOA
involved in regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
26340092 GOA
involved in regulation of chromosome organization IMP
IMP: Inferred from mutant phenotype
26340092 GOA
involved in regulation of proteasomal protein catabolic process IMP
IMP: Inferred from mutant phenotype
18162577 GOA
Cellular Component GO Annotation Evidence References Source
part of Ino80 complex IDA
IDA: Inferred from direct assay
18922472 GOA
located in cytosol IDA
IDA: Inferred from direct assay
18922472 GOA
located in nucleus IDA
IDA: Inferred from direct assay
18922472 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UCHL5 Protein Structure

Peptidase_C12

Peptidase_C12: Ubiquitin carboxyl-terminal hydrolase, family 1 (7 - 211)

  • 0
  • 100
  • 200
  • 300
  • 329 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase isozyme L5

  • INO80 complex subunit R

UCHL5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UCHL5 Q9Y5K5 TFPT Homo sapiens P0C1Z6
Anti Tag CoIP
19615732
Intra
UCHL5 Q9Y5K5 TFPT Homo sapiens P0C1Z6
Anti Tag CoIP
18922472
Intra
UCHL5 Q9Y5K5 NFRKB Homo sapiens Q6P4R8
Anti Tag CoIP
33961781
Intra
UCHL5 Q9Y5K5 NFRKB Homo sapiens Q6P4R8
Anti Tag CoIP
18922472
Intra
UCHL5 Q9Y5K5 NFRKB Homo sapiens Q6P4R8
Y2H Prey Pooling
25416956
Intra
UCHL5 Q9Y5K5 NFRKB Homo sapiens Q6P4R8
Validated Y2H
25416956
Intra
UCHL5 Q9Y5K5 NFRKB Homo sapiens Q6P4R8
Anti Tag CoIP
19615732
Intra
UCHL5 Q9Y5K5 NFRKB Homo sapiens Q6P4R8
Pull Down
18922472
Intra
UCHL5 Q9Y5K5 PSMD2 Homo sapiens Q13200
Anti Tag CoIP
19490896
Intra
UCHL5 Q9Y5K5 PSMD2 Homo sapiens Q13200
Anti Tag CoIP
18922472
Intra
UCHL5 Q9Y5K5 PSMD2 Homo sapiens Q13200
Anti Tag CoIP
19615732
Intra
UCHL5 Q9Y5K5 PSMD2 Homo sapiens Q13200
Anti Tag CoIP
16990800
Intra
UCHL5 Q9Y5K5 PSMD2 Homo sapiens Q13200
Anti Tag CoIP
33961781
Intra
UCHL5 Q9Y5K5 PSMA6 Homo sapiens P60900
Anti Tag CoIP
19490896
Intra
UCHL5 Q9Y5K5 PSMA6 Homo sapiens P60900
Anti Tag CoIP
18922472
Intra
UCHL5 Q9Y5K5 PSMA6 Homo sapiens P60900
Anti Tag CoIP
16990800
Intra
UCHL5 Q9Y5K5 PSMD4 Homo sapiens P55036
Anti Tag CoIP
19615732
Intra
UCHL5 Q9Y5K5 PSMD4 Homo sapiens P55036
Anti Tag CoIP
33961781
Intra
UCHL5 Q9Y5K5 PSMD4 Homo sapiens P55036
Pull Down
17139257
Intra
UCHL5 Q9Y5K5 PSMD4 Homo sapiens P55036
Anti Tag CoIP
19490896
Intra
UCHL5 Q9Y5K5 PSMD4 Homo sapiens P55036
Anti Tag CoIP
18922472
Intra
UCHL5 Q9Y5K5 INO80E Homo sapiens Q8NBZ0
Anti Tag CoIP
18922472
Intra
UCHL5 Q9Y5K5 INO80E Homo sapiens Q8NBZ0
Anti Tag CoIP
19615732
Intra
UCHL5 Q9Y5K5 ACTR8 Homo sapiens Q9H981
Anti Tag CoIP
33961781
Intra
UCHL5 Q9Y5K5 ACTR8 Homo sapiens Q9H981
Anti Tag CoIP
18922472
Intra
UCHL5 Q9Y5K5 ADRM1 Homo sapiens Q16186
Anti Tag CoIP
33961781
Intra
UCHL5 Q9Y5K5 ADRM1 Homo sapiens Q16186
Y2H
21516116
Intra
UCHL5 Q9Y5K5 ADRM1 Homo sapiens Q16186
Pull Down
17139257
Intra
UCHL5 Q9Y5K5 ADRM1 Homo sapiens Q16186
Density Sedimentation
16990800
Intra
UCHL5 Q9Y5K5 ADRM1 Homo sapiens Q16186
Anti Tag CoIP
18922472
Intra
UCHL5 Q9Y5K5 ADRM1 Homo sapiens Q16186
Y2H Prey Pooling
25416956
Intra
UCHL5 Q9Y5K5 ADRM1 Homo sapiens Q16186
Anti Tag CoIP
19615732
Intra
UCHL5 Q9Y5K5 ADRM1 Homo sapiens Q16186
Validated Y2H
25416956
Intra
UCHL5 Q9Y5K5 ADRM1 Homo sapiens Q16186
Anti Tag CoIP
19490896
Intra
UCHL5 Q9Y5K5 ADRM1 Homo sapiens Q16186
Pull Down
16990800
Intra
UCHL5 Q9Y5K5 ADRM1 Homo sapiens Q16186
Anti Tag CoIP
16990800
Cross: Cross-species interaction Intra: Intraspecies interaction

UCHL5 Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P82594 UCHL5 Antibody (YA2339) WB, ICC/IF, IP Human, Mouse, Rat
HY-P82594A UCHL5 Antibody (YA2339)(PBS only) WB, ICC/IF, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Machado-Joseph Disease

  • SCA3

  • MJD

  • Spinocerebellar Ataxia 3

  • Azorean Disease

  • Spinocerebellar Ataxia Type 3

  • Spinocerebellar Atrophy

  • Azorean Neurologic Disease

  • Spinopontine Atrophy

  • Nigrospinodentatal Degeneration

  • Spinocerebellar Atrophy Iii

  • Spinocerebellar Atrophy Type 3

  • Azorean Ataxia

  • Azorean Disease Of The Nervous System

  • Machado Disease

  • Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia

  • Disease, Machado-Joseph

  • Ataxia, Spinocerebellar
Autosomal Dominant Cerebellar Ataxia

  • Spinocerebellar Ataxia

  • Adca

  • Pierre Marie Cerebellar Ataxia

  • Ataxia, Spinocerebellar

  • Sca

  • Autosomal Dominant Spinocerebellar Ataxia

  • Spinocerebellar Ataxias
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-13989 b-AP15 98.05% Unkown
HY-149230 USP28-IN-4 Inhibitor 98.86% Unkown
HY-149229 USP28-IN-3 Inhibitor 98.26% Unkown
HY-D1236 Fluorescent brightener 71 Inhibitor / Unkown
HY-149228 USP28-IN-2 Inhibitor / Unkown
HY-164689 Cadmium pyrithione Inhibitor / Unkown
HY-RS15402 UCHL5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-15432 (E/Z)-NSC-687852 / Unkown
HY-RS18192 Uchl5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24666 Uchl5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus UCHL5 VGNC VGNC:97678
Canis familiaris UCHL5 VGNC VGNC:48105
Mus musculus UCHL5 MGD MGI:1914848
Bos taurus UCHL5 VGNC VGNC:36633
Rattus norvegicus UCHL5 RGD RGD:1305414
Macaca mulatta UCHL5 VGNC VGNC:79197
Others UCHL5 NCBI