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Cat. No.: HY-156003

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HDAC-IN-64

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

HDAC-IN-64 (Compound 13) is a HDAC inhibitor. HDAC-IN-64 inhibits HDAC4/5/6/7/9 with IC₅₀s of 24, 45, 85, 31, 37 nM. HDAC-IN-64 has anti-proliferative activity and anti-migration properties on prostate cancer (PCA) cells. HDAC-IN-64 inhibits LNCaP and RWPE-1 cell growth with GI₅₀ of 0.32 and 1.1 μM respectively.

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CAS No.: 3052688-17-9
화학식: C₁₅H₈ClF₄N₇O
분자량:413.72

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

HDAC-IN-64 Chemical Structure

CAS No.: 3052688-17-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Publications (1)
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References
Calculators
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Bioz

Biological Activity

제품 설명

IC₅₀ & Target

24, 45, 85, 31, 37 nM (HDAC4/5/6/7/9)^[1]

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
LNCaP	GI₅₀	0.32 μM Compound: 13	Antiproliferative activity against human LNCaP cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human LNCaP cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37633202]
RWPE-1	GI₅₀	1.1 μM Compound: 13	Antiproliferative activity against human RWPE-1 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human RWPE-1 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37633202]

Chemical Information

CAS No. 3052688-17-9
분자량 413.72
화학식 C₁₅H₈ClF₄N₇O
SMILES

NC1=NC(Cl)=C2N=CN(CC3=CC=C(C4=NOC(C(F)(F)F)=N4)C=C3F)C2=N1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Int J Parasitol Drugs Drug Resist

2026 May 17;31:100649.

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Moi D, et al. Discovery of potent pyrrolo-pyrimidine and purine HDAC inhibitors for the treatment of advanced prostate cancer. Eur J Med Chem. 2023 Aug 16;260:115730. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

HDAC-IN-64

1 Cited Publications

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Biological Activity
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- IC₅₀ & Target
Chemical Information
Publications (1)
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HDAC-IN-64

Publications Citing Use of MedChemExpress (MCE) HDAC-IN-64

All HDAC Isoforms

Biological Activity

Chemical Information

Publications (1)

순도&문서

References

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HDAC-IN-64 Related Classifications

HY-156003 Related Classifications