IBE-667
IBE-667 is a LFA-1 integrin agonist with a Kd value of 52 nM. IBE-667 increases the stability of the open conformation of LFA-1 and enhances its affinity for ICAM-1. IBE-667 can be used in studies related to leukocyte adhesion deficiency.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 1609659-32-6
- 화학식: C25H25N5O2
- 분자량:427.51
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
[1]|
αLβ2 |
In Vitro
IBE-667 binds directly to purified LFA-1 I domain with a Kd of 52 nM[1].
IBE-667 acts as an agonist to enhance binding between purified LFA-1 I domain and soluble ICAM-1, with a dissociation constant of 76 nM for the ternary complex[1].
IBE-667 (1-1000 μM) dose-dependently enhances soluble ICAM-1 binding to in vitro activated primary human T-cells via an LFA-1-dependent mechanism[1].
IBE-667 (0-120 μM) dose-dependently induces aggregation of in vitro activated primary human T-cells via an LFA-1-dependent mechanism[1].
IBE-667 acts as an agonist for αₗβ2 integrin (LFA-1) on activated T-cells, enhancing ICAM-1 binding via allosteric interaction with the αₗ domain[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1609659-32-6
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분자량 427.51
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화학식 C25H25N5O2
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SMILES
O=C(NC)C1=CC=C(C=C1)N2N=C(C=3C=CC(=CC3)C(=O)NCCCN)C=4C=CC=CC42
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IBE-667 Related Classifications
HY-150181 Related Classifications
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