country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-182779

Copy Link Print Information

JNUTS013

JNUTS013 is a NLRP3 inflammasome inhibitor. JNUTS013 promotes proteasome-dependent degradation of NLRP3 and inhibits the release of downstream cytokines. JNUTS013 downregulates the expression of inflammation-related proteins including iNOS and COX-2. JNUTS013 exhibits anti-inflammatory activity and can be used in the research of inflammatory diseases.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2763983-45-3
화학식: C₂₀H₂₂O₆
분자량:358.39

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

JNUTS013 Chemical Structure

CAS No.: 2763983-45-3

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

COX-2

NLRP3 inflammasome

All NOD-like Receptor (NLR) Isoforms :

All COX Isoforms :

All NO Synthase Isoforms :

In Vitro

JNUTS013 (10 μM; 24 h) inhibits LPS (HY-D1056)-induced NO production in RAW264.7 macrophages, while cells maintain high viability under this condition^[1].
JNUTS013 (10 μM; 24 h) inhibits LPS-induced expression of iNOS, COX-2 and NLRP3 proteins in RAW264.7 macrophages^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

RAW264.7 macrophages treated LPS
Concentration:

10 μM
Incubation Time:

24 h
Result:

Downregulated the expression of LPS-induced iNOS, COX-2, and NLRP3 proteins in RAW264.7 macrophages.

Chemical Information

CAS No. 2763983-45-3
분자량 358.39
화학식 C₂₀H₂₂O₆
SMILES

OC1=C(C(/C=C/C2=CC(OC)=C(OC)C(OC)=C2)=O)C=C(C)C(O)=C1C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Zhang B, et al. Design and synthesis of sorbicillinoid-derived bibenzyl and brominated analogues as anti-inflammatory agents. Bioorg Med Chem Lett. Published online March 30, 2026. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

100 mg

견적 받기 해외재고보유

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

JNUTS013

All NOD-like Receptor (NLR) Isoforms

All COX Isoforms

All NO Synthase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

JNUTS013 Related Classifications

HY-182779 Related Classifications