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United States

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Cat. No.: HY-175542

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KB-15

KB-15 is a STAT3 inhibitor. KB-15 exhibits potent anti-proliferative activity against AGS gastric cancer cells (IC₅₀ = 0.29 μM) and BGC-823 gastric cancer cells (IC₅₀ = 0.65 μM). KB-15 exerts anti-tumor effects by inhibiting STAT3 phosphorylation, downregulating HO-1 expression, and promoting intracellular ROS accumulation. KB-15 induces G0/G1 phase cell cycle arrest and apoptosis, as well as suppresses colony formation and migration of gastric cancer cells. KB-15 demonstrates excellent anti-tumor efficacy in BGC-823 subcutaneous xenograft model. KB-15 can be used for the study of gastric cancer.

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화학식: C₁₈H₁₂Cl₄N₂O₂
분자량:430.11

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

KB-15 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All STAT Isoforms :

All PARP Isoforms :

In Vitro

KB-15 (72 h) exhibits potent anti-proliferative activity against AGS gastric cancer cells (IC₅₀ = 0.29 μM) and BGC-823 gastric cancer cells (IC₅₀ = 0.65 μM)^[1].
KB-15 (0.25-2 μM, 14 days) shows potent colony formation inhibitory activity against AGS and BGC-823 gastric cancer cells^[1].
KB-15 (0.5-2 μM, 24 h) demonstrates potent ROS-inducing activity in BGC-823 cells^[1].
KB-15 (0.25-2 μM, 24-36 h) exhibits potent G0/G1 phase arrest activity and induces apoptosis in AGS and BGC-823 cells^[1].
KB-15 (0.5-2 μM, 24 h) inhibits STAT3 activation in a concentration-dependent manner and downregulates HO-1 in BGC-823 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

AGS and BGC-823 cells
Concentration:

0.25, 0.5, 1, 2 μM
Incubation Time:

36 h
Result:

Induced concentration-dependent increase in the proportion of G0/G1 phase cells.

Apoptosis Analysis^[1]

Cell Line:

BGC-823 cells
Concentration:

0.5, 1, 2 μM
Incubation Time:

24 h
Result:

Increased the total apoptosis rate in a concentration-dependent manner.
Upregulated pro-apoptotic proteins Cleaved-PARP and Bax.

Western Blot Analysis^[1]

Cell Line:

BGC-823 cells
Concentration:

0.5, 1, 2 μM
Incubation Time:

24 h
Result:

Inhibited STAT3 activation in a concentration-dependent manner and downregulated HO-1.

Parmacokinetics

Species	Dose	Route	T_1/2	C_max	T_max	AUC_0-t	AUC_0-∞	MRT_0-t	MRT_0-∞
Mice^[1]	5 mg/kg	i.p.	2.33 h	659 ng/mL	0.333 h	1.167 ng/L.h	1.175 ng/L.h	1.60 h	1.70 h

In Vivo

KB-15 (2.5 mg/kg, i.p., once daily, 14 consecutive days) demonstrates excellent anti-tumor efficacy in BGC-823 subcutaneous xenograft model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BGC-823 cells (5 × 10⁷ in serum-free medium) were subcutaneously implanted into the left axillary area of 6-week-old male BALB/c (nu/nu) nude mice^[1]
Dosage:

2.5 mg/kg
Administration:

i.p. once daily for 14 consecutive days
Result:

Achieved a tumor growth inhibition (TGI) rate of 53.3% at a dose of 2.5 mg/kg.
Reduced the expression of phosphorylated STAT3 (p-STAT3) and HO-1 protein in BGC-823 xenograft tumor tissues.
Increased the expression of pro-apoptotic proteins Cleaved-PARP and Bax, and decreased the expression of apoptotic protease Procaspase-3 in tumor tissues.

Chemical Information

분자량 430.11
화학식 C₁₈H₁₂Cl₄N₂O₂
SMILES

ClC1=C(Cl)C=CC(/C=C/C(NNC(/C=C/C2=CC(Cl)=C(Cl)C=C2)=O)=O)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wu J, et al. Design, synthesis and anti-gastric cancer activity of stable Bisamide curcumin analogues. Bioorg Chem. 2025 Jul 23;164:108793. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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