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Cat. No.: HY-147196

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KB03-SLF

KB03-SLF is a bifunctional PROTAC, formed by conjugating the cysteine-targeting KB03 exploratory fragment with SLF (HY-114872), an FKBP12 ligand that does not support the degradation of FKBP12^NLS. KB03-SLF fails to degrade nuclear-localized FKBP12^NLS in cells, nor can it mediate the interaction between DCAF16 and FKBP12^NLS in a manner similar to KB02-SLF (HY-129610).
(Pink: FKBP51 and FKBP12 ligand (HY-114872); Blue: Cereblon ligand (HY-169968); Black: linker (HY-W040168)).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2384184-42-1
화학식: C₅₀H₆₃ClF₃N₅O₁₂
분자량:1018.51

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

KB03-SLF Chemical Structure

CAS No.: 2384184-42-1

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

KB03-SLF is a bifunctional PROTAC, formed by conjugating the cysteine-targeting KB03 exploratory fragment with SLF (HY-114872), an FKBP12 ligand that does not support the degradation of FKBP12^NLS. KB03-SLF fails to degrade nuclear-localized FKBP12^NLS in cells, nor can it mediate the interaction between DCAF16 and FKBP12^NLS in a manner similar to KB02-SLF (HY-129610)^[1]. (Pink: FKBP51 and FKBP12 ligand (HY-114872); Blue: Cereblon ligand (HY-169968); Black: linker (HY-W040168)).

IC₅₀ & Target

^[1]

FKBP12

Cereblon

All PROTACs Isoforms :

In Vitro

KB03-SLF (2 µM; 8-24 h) does not support DCAF16-mediated degradation of nuclear-localized FLAG-FKBP12_NLS in HEK293T cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Western Blot Analysis^[1]

View Protocol

Cell Line:

HEK293T cells stably expressing nuclear-localized FLAG-FKBP12_NLS
Concentration:

5 µM
Incubation Time:

2 h
Result:

Did not promote degradation of nuclear-localized FLAG-FKBP12_NLS.
Did not induce KB02-SLF-dependent enrichment of DCAF16 with FLAG-FKBP12_NLS in co-immunoprecipitation experiments.

Chemical Information

CAS No. 2384184-42-1
분자량 1018.51
화학식 C₅₀H₆₃ClF₃N₅O₁₂
SMILES

O=C([C@H]1N(CCCC1)C(C(C(C)(C)CC)=O)=O)O[C@@H](C2=CC(NC(CCOCCOCCNC(CCNC(C3=CC(NC(CCl)=O)=CC(C(F)(F)F)=C3)=O)=O)=O)=CC=C2)CCC4=CC(OC)=C(C=C4)OC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nature chemical biology. 2019 Jul;15(7):737-746. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

KB03-SLF

All PROTACs Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

KB03-SLF Related Classifications

HY-147196 Related Classifications

Bioz

Keywords

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