country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-135079

Copy Link Print Information

Lerimazoline

Lerimazoline is a selective 5-HT1D receptor agonist with K_i values of 72 and 3480 nM for h5-HT1D and h5-HT1B. Lerimazoline inhibits Forskolin (HY-15371)-stimulated cAMP production and induces contractions in rabbit saphenous vein preparations. Lerimazoline can be used for the research of migraine.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 54765-26-3
화학식: C₁₃H₁₈N₂
분자량:202.30

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Lerimazoline Chemical Structure

CAS No.: 54765-26-3

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

5-HT_1D Receptor

72 nM (Ki)

5-HT_1B Receptor

3480 nM (Ki)

All 5-HT Receptor Isoforms :

In Vitro

Lerimazoline (Compound 29) (0.1-1 μM; 60 min) binds to human h5-HT₁B receptors with a K_i of 3480 nM^[1].
Lerimazoline (0.1-1 μM; 60 min) binds to human h5-HT₁D receptors with a K_i of 72 nM, displaying 48-fold selectivity for h5-HT₁D over h5-HT₁B receptors^[1].
Lerimazoline (1-10 μM; 30 min) inhibits Forskolin (HY-15371)-stimulated cAMP production in transfected CHO Pro 5 cells^[1].
Lerimazoline (10-10000 nM) induces contractions of rabbit saphenous vein with a 95% of the maximal effect^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 54765-26-3
분자량 202.30
화학식 C₁₃H₁₈N₂
SMILES

CC1=C(CC2=NCCN2)C(C)=CC(C)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Law H, et al. Benzylimidazolines as h5-HT1B/1D serotonin receptor ligands: a structure-affinity investigation. J Med Chem. 1998 Jun 18;41(13):2243-51. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

견적 받기 해외재고보유

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Lerimazoline

All 5-HT Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Lerimazoline Related Classifications

HY-135079 Related Classifications