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Cat. No.: HY-P990639

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Biologically Validated

NI-0801

Name: NI-0801
Brand: MedChemExpress
SKU: HY-P990639
Price: 340.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: EB 06)

고객리뷰

Based on 1 Customer Validation

NI-0801 (EB 06) is a CXCL10 inhibitor with a K_d of 140 pM. NI-0801 blocks the CXCL10-CXCR3 interaction. NI-0801 selectively binds human CXCL10 but not CXCL9 or CXCL11, and inhibits CXCL10-induced calcium flux, chemotaxis, and lymphocyte transendothelial migration.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity : 99.19%
분자량:146.08 kDa

보관:

Shipping with dry ice

Please store the product under the recommended conditions in the Certificate of Analysis.

NI-0801 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Gene ID
- Accession
- Conjugated
- Reconsititution
- 신청
- Verified Bioactivity
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

^[3]

CXCL10

140 pM (Kd)

All CXCR Isoforms :

In Vitro

Cytokines and Chemokines

NI-0801 (K_d 140 pM) binds human CXCL10 with a K_d of 140 pM and does not bind CXCL9 or CXCL11^[3].
NI-0801 inhibits CXCL10-induced calcium flux and chemotaxis in vitro^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Gene ID

3627 [NCBI]

Accession

P02778

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

신청

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized Human IP-10/CXCL10 Protein can bind NI-0801. The EC₅₀ for this effect is 2.326 ng/mL.

Chemical Information

Appearance Liquid
분자량 146.08 kDa
Color Colorless to light yellow
Synonyms

EB 06
선적

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (259 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Bowlus CL, et al. Therapeutic trials of biologics in primary biliary cholangitis: An open label study of abatacept and review of the literature. Journal of autoimmunity. 2019 Jul;101:26-34.

[2]. Bonvin P, et al. Antibody neutralization of CXCL10 in vivo is dependent on binding to free and not endothelial-bound chemokine: implications for the design of a new generation of anti-chemokine therapeutic antibodies. Journal of Biological Chemistry. 2017 Mar 10;292(10):4185-97.

[3]. de Graaf KL, et al. NI-0801, an anti-chemokine (C-X-C motif) ligand 10 antibody, in patients with primary biliary cholangitis and an incomplete response to ursodeoxycholic acid. Hepatol Commun. 2018 Mar 23;2(5):492-503.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Gene ID
- Accession
- Conjugated
- Reconsititution
- 신청
- Biological Activity
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

NI-0801

All CXCR Isoforms