Penipanoid C
Penipanoid C (Compound 9) is a BRD4 inhibitor. Penipanoid C can be isolated from marine sediment-derived fungus Penicillium paneum SD-44. Penipanoid C has anti-inflammatory activity and cytotoxic activity against the SMMC-7721 cells. Penipanoid C can be used for inflammatory diseases research.
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- CAS No.: 1442381-95-4
- 화학식: C15H10N2O3
- 분자량:266.25
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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BRD4 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
>50 μM
Compound: 3a
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Cytotoxicity against human HepG2 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
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[PMID: 34237623] |
Chemical Information
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CAS No. 1442381-95-4
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분자량 266.25
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화학식 C15H10N2O3
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SMILES
O=C1N=C(C(C2=CC=C(C=C2)O)=O)NC3=C1C=CC=C3
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Structure Classification
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Initial Source
Penicillium oxalicum
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Chen S, et al. Marine natural product-inspired discovery of novel BRD4 inhibitors with anti-inflammatory activity. Eur J Med Chem. 2025 Feb 15;284:117193. [Content Brief]
[2]. Li CS, et al. Triazole and dihydroimidazole alkaloids from the marine sediment-derived fungus Penicillium paneum SD-44. J Nat Prod. 2011 May 27;74(5):1331-4. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Penipanoid C Related Classifications
HY-N16067 Related Classifications
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