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United States

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Cat. No.: HY-N12561

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Pestanoid A

Pestanoid A is a rearranged pimarane diterpenoid osteoclastogenesis inhibitor with an IC₅₀ of 4.2 μM. Pestanoid A can be isolated from the marine mesophotic zone chalinidae sponge-associated fungus, Pestalotiopsis sp. NBUF145. Pestanoid A inhibits the receptor activator of NF-kB ligand-induced MAPK and NF-κB signaling by suppressing the phosphorylation of ERK1/2-JNK1/2-p38 MAPKs and NF-κB nuclear translocation. Pestanoid A can be used for the study of osteoporosis.

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화학식: C₂₀H₂₆O₆
분자량:362.42

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Pestanoid A Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All ERK Isoforms :

All JNK Isoforms :

All p38 MAPK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Monocyte	CC₅₀	>30 μM Compound: 1	Cytotoxicity against C57BL/6 mouse bone marrow monocytes assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against C57BL/6 mouse bone marrow monocytes assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38194474]
Monocyte	IC₅₀	4.2 μM Compound: 1	Anti-osteoclastogensis in C57BL/6 mouse bone marrow monocytes assessed as inhibition of RANKL/M-CSF induced osteoclastogenesis at 10 uM incubated for 5 days Anti-osteoclastogensis in C57BL/6 mouse bone marrow monocytes assessed as inhibition of RANKL/M-CSF induced osteoclastogenesis at 10 uM incubated for 5 days	[PMID: 38194474]

Chemical Information

분자량 362.42
화학식 C₂₀H₂₆O₆
SMILES

C=C1CC[C@@]2([H])[C@@](C(C(C[C@@]3(C)[C@H](CO)OC(C3)=O)=CC(O2)=O)=O)(C)[C@@H]1C
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
- Microorganism
Pestalotiopsis
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang T, et al. Pestanoid A, a Rearranged Pimarane Diterpenoid Osteoclastogenesis Inhibitor from a Marine Mesophotic Zone Chalinidae Sponge-Associated Fungus, Pestalotiopsis sp. NBUF145[J]. Journal of Natural Products, 2024. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Pestanoid A

All ERK Isoforms

All JNK Isoforms

All p38 MAPK Isoforms