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Cat. No.: HY-19137

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Pibrozelesin

Name: Pibrozelesin
Brand: MedChemExpress
SKU: HY-19137
Availability: PreOrder

(Synonyms: KW 2189 free base)

Pibrozelesin (KW 2189 free base) is the derivative of antibiotic Duocarmycin B2. Pibrozelesin exhibits antitumor activity, inhibits proliferation of cell H69 with an IC₅₀ of 1.9 μM. Pibrozelesin induces the DNA strand breaks upon activation via carboxyl esterase.

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CAS No.: 154889-68-6
화학식: C₃₂H₃₆BrN₅O₈
분자량:698.56

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Pibrozelesin Chemical Structure

CAS No.: 154889-68-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Antibiotic Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	18.1 ng/mL Compound: 7	Concentration required to inhibit the growth of HeLaS3 human uterine cervix carcinoma cells by 50% Concentration required to inhibit the growth of HeLaS3 human uterine cervix carcinoma cells by 50%	[PMID: 10212131]
HeLa	IC₅₀	18.1 ng/mL Compound: 7	Concentration required for 50% inhibition of human uterine Cervix Carcinoma cells (HeLaS3) Concentration required for 50% inhibition of human uterine Cervix Carcinoma cells (HeLaS3)	10.1016/S0960-894X(97)00288-6

Chemical Information

CAS No. 154889-68-6
분자량 698.56
화학식 C₃₂H₃₆BrN₅O₈
SMILES

BrC[C@H]1C2=C(N(C1)C(C(NC3=C4OC)=CC3=CC(OC)=C4OC)=O)C=C(OC(N5CCN(CC5)C)=O)C6=C2C(C(OC)=O)=C(C)N6
Synonyms

KW 2189 free base
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ogasawara H, et al., A novel antitumor antibiotic, KW-2189 is activated by carboxyl esterase and induces DNA strand breaks in human small cell lung cancer cells. Jpn J Cancer Res. 1994 Apr;85(4):418-25. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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