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Cat. No.: HY-170792

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PRMT5-IN-48

PRMT5-IN-48 (compound D3) is an orally effective PRMT5 inhibitor (IC₅₀=20.7 nM) with anticancer activity. PRMT5-IN-48 can inhibit the growth of various cancer cells, induce apoptosis (apoptosis), and arrest the cell cycle at the G0/G1 phase. PRMT5-IN-48 can be used for non-Hodgkin lymphoma (NHL) research.

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CAS No.: 2640287-77-8
화학식: C₃₀H₃₇N₅O₃
분자량:515.65

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PRMT5-IN-48 Chemical Structure

CAS No.: 2640287-77-8

사이즈

가격

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수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- Parmacokinetics
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

PRMT5^[1]

All Histone Methyltransferase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-468	IC₅₀	7.4 nM Compound: 24	Antiproliferative activity against human MDA-MB-468 assessed as cell growth inhibition measured after 7 days by CCK-8 assay Antiproliferative activity against human MDA-MB-468 assessed as cell growth inhibition measured after 7 days by CCK-8 assay	[PMID: 37366223]
NCI-H358	IC₅₀	5 nM Compound: 24	Antiproliferative activity against human NCI-H358 assessed as cell growth inhibition measured after 7 days by CCK-8 assay Antiproliferative activity against human NCI-H358 assessed as cell growth inhibition measured after 7 days by CCK-8 assay	[PMID: 37366223]
Z-138	IC₅₀	2.2 nM Compound: 24	Antiproliferative activity against human Z138 cells assessed as cell growth inhibition measured after 7 days by CCK-8 assay Antiproliferative activity against human Z138 cells assessed as cell growth inhibition measured after 7 days by CCK-8 assay	[PMID: 37366223]

Parmacokinetics

Species	Dose	Route	Note	T_1/2	Plasma Concentration	AUC	MRT	Clearance (CL)	V_d	T_max	Bioavailability
Rat	10 mg/kg	p.o.	SD Rats	0.4 h	1366.5 ng/mL	771 ng·h/mL	0.5 h	2.5 L/h/kg	1.4 L/kg	/	/
Rat	2 mg/kg	i.v.	SD Rats	2.2 h	894 ng/mL	1028.2 ng·h/mL	1.7 h	/	/	0.1 h	26.7 %

Chemical Information

CAS No. 2640287-77-8
분자량 515.65
화학식 C₃₀H₃₇N₅O₃
SMILES

O=C1C2=CC(NC3CC4(C3)CN(C4)C(C)=O)=NC=C2C5(CN1C[C@@H](CN6CCC(C=CC=C7)=C7C6)O)CC5
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li QQ, et al. Design, Synthesis, and Biological Evaluation of 3,4-Dihydroisoquinolin-1(2H)-one Derivatives as Protein Arginine Methyltransferase 5 Inhibitors for the Treatment of Non-Hodgkin's Lymphoma. J Med Chem. 2025 Jan 9;68(1):108-134. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
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PRMT5-IN-48

All Histone Methyltransferase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

PRMT5-IN-48 Related Classifications

HY-170792 Related Classifications