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Cat. No.: HY-155065

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SB-1295

SB-1295 is an orally active CDK9/T1 inhibitor (IC₅₀=0.17 μM). SB-1295 shows antiproliferative activity in HCT 116 and MIA PaCa-2 cells. SB-1295 also induces MIA PaCa-2 cell death by inducing intracellular ROS production, reducing mitochondrial membrane potential and inducing apoptosis. SB-1295 has the potential to study cancer.

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화학식: C₂₃H₂₂ClNO₆
분자량:443.88

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (246 KB)

SB-1295 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

IC50: 0.17 μM (CDK9/T1)^[1].

All CDK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	GI₅₀	5.1 μM Compound: 2b; SB-1295, DD-35	Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37302342]
HEK293	GI₅₀	90.32 μM Compound: 2b; SB-1295, DD-35	Antiproliferative activity against HEK293 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against HEK293 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37302342]
MIA PaCa-2	GI₅₀	6.07 μM Compound: 2b; SB-1295, DD-35	Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37302342]

Chemical Information

분자량 443.88
화학식 C₂₃H₂₂ClNO₆
SMILES

OC1=C2C(OC(/C=C/C3=CC=CC=C3Cl)=CC2=O)=C([C@]4([H])[C@H](O)C[N+](C)([O-])CC4)C(O)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (246 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

SB-1295

All CDK Isoforms

Biological Activity

제품 설명

IC50 & Target

Cellular Effect

Chemical Information

순도&문서

Calculators

Help & FAQs

SB-1295 Related Classifications

HY-155065 Related Classifications

Bioz

Keywords

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