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Cat. No.: HY-116603

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SB-236057

SB-236057 is an inverse agonist of the 5-HT_1B receptor that exhibits strong skeletal teratogenicity in rodents and rabbits. SB-236057 affects gene expression during embryonic development through interference with the Notch signaling pathway and interaction with r-esp1. SB-236057 induces somatic patterning and tail extension defects in rat embryos during early organogenesis.

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CAS No.: 180083-49-2
화학식: C₃₃H₃₄N₄O₃
분자량:534.65

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

SB-236057 Chemical Structure

CAS No.: 180083-49-2

Amount: USD 0.00

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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IC₅₀ & Target

5-HT_1B Receptor

All 5-HT Receptor Isoforms :

Chemical Information

CAS No. 180083-49-2
분자량 534.65
화학식 C₃₃H₃₄N₄O₃
SMILES

O=C(N1C2=CC3=C(C=C2CC1)OCC34CCN(CC4)CC)C5=CC=C(C6=C(C)C=C(C7=NN=C(C)O7)C=C6)C=C5
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Augustine‐Rauch K A, et al. Evidence for a molecular mechanism of teratogenicity of SB‐236057, a 5‐HT1B receptor inverse agonist that alters axial formation[J]. Birth Defects Research Part A: Clinical and Molecular Teratology, 2004, 70(10): 789-807. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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SB-236057

All 5-HT Receptor Isoforms

Biological Activity

제품 설명

IC50 & Target

Chemical Information

순도&문서

References

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