Setomimycin
Setomimycin is a potent antibiotic. Setomimycin inhibits the SARS-CoV-2 Mpro enzyme with an IC50 value of 12.02 µM. Setomimycin shows anti-inflammatory and antioxidant properties. Setomimycin shows antiproliferative and antitumor activity.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 69431-87-4
- 화학식: C34H28O9
- 분자량:580.58
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
All Antibiotic Isoforms
More
Biological Activity
제품 설명
IC50 & Target
IC50: 12.02 µM (SARS-CoV-2 Mpro)[1]
In Vitro
Setomimycin (0.01-1 µM) inhibits the release of cytokines IL-1β, IL-6 and TNF-α and nitric oxide release from LPS stimulated RAW 264.7 cells in a dose-dependent manner[1].
Setomimycin (compound 1) shows antimicrobial activity with MICs of 8, 4, 16, 4 μg/mL for Staphylococcus aureus, Bacillus cereus, Bacillus subtilis, Micrococcus luteus, respectively[2].
Setomimycin (0-100 µM; 5 days) shows antiproliferative activity and inhibits colony formation[2].
Setomimycin (4, 5.5, 7 µM) decreases the protein expression of p-MEK, p-ERK, Bcl-2, increases the expression of Par-4[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:A549; HOP-92; Panc-1; MiaPaca-2 cells
-
Concentration:0-100 µM
-
Incubation Time:44 h
-
Result:Showed antiproliferative activity with IC50s of 11.45, >100, 48, 4.57 µM for A549; HOP-92; Panc-1; MiaPaca-2 cells, respectively.
-
Cell Line:MCF-7, HCT-116 cells
-
Concentration:4, 5.5, 7 µM
-
Incubation Time:
-
Result:Decreased the protein expression of p-MEK, p-ERK, Bcl-2, increased the expression of Par-4 in a dose-dependent manner.
In Vivo
Pharmacokinetic Parameters of Setomimycin in female BALB/c mice[2].
| Pharmacokinetic parameters | Value |
| Cmax (ng/ml) | 694 ± 62 |
| Tmax (h) | 0.3 ± 0.1 |
| T1/2 (h) | 2.3 ± 0.5 |
| AUC0-t (ng.h/mL) | 2613 ± 111 |
| AUC0-α (ng.h/mL) | 2734 ± 108 |
| Vd (L/Kg) | 24 ± 4 |
| Cl (L/h/Kg) | 7.4 ± 0.3 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:6 weeks, 25-30 g, female BALB/c mice (4T1 cells)[2]
-
Dosage:20 mg/kg
-
Administration:I.p.; every other day for two weeks
-
Result:Decreased primary tumor weight (76%) and volume (90.5%).
Chemical Information
-
CAS No. 69431-87-4
-
분자량 580.58
-
화학식 C34H28O9
-
SMILES
O=C1CC(C)(O)C(C(C)=O)C2=C1C(O)=C3C(O)=CC=CC3=C2C4=C5C=CC=C(O)C5=C(O)C6=C4C(C(C)=O)C(C)=CC6=O
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Manhas RS, et al. Setomimycin as a potential molecule for COVID‑19 target: in silico approach and in vitro validation. Mol Divers. 2023 Apr;27(2):619-633. [Content Brief]
[2]. Manhas RS, et al. Isolation and anticancer activity evaluation of rare Bisaryl anthraquinone antibiotics from novel Streptomyces sp. strain of NW Himalayan region. Chem Biol Interact. 2022 Sep 25;365:110093. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Setomimycin Related Classifications
HY-124439 Related Classifications
Powered by Bioz