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Cat. No.: HY-175293

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SMU-C68

SMU-C68 is a highly selective small-molecule TLR1/2 heterodimer agonist (EC₅₀=0.009 μM). SMU-C68 activates NF-κB and MAPK pathways to promote pro-inflammatory cytokine release (e.g., TNF-α, IL-1β). SMU-C68 is promising for research of cancers.

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CAS No.: 2677039-75-5
화학식: C₂₁H₂₁N₃O₂S₂
분자량:411.54

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

SMU-C68 Chemical Structure

CAS No.: 2677039-75-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
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Calculators
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Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

TLR1

TLR2

All Toll-like Receptor (TLR) Isoforms :

All NF-κB Isoforms :

All p38 MAPK Isoforms :

Chemical Information

CAS No. 2677039-75-5
분자량 411.54
화학식 C₂₁H₂₁N₃O₂S₂
SMILES

CC(OC(C1=C(SC2=C1CCC2)NC(NC3=C4C=CC=NC4=CC=C3)=S)=O)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zeng X, et al. Discovery of potent, selective human TLR1/2 agonists: N-quinoline-N'-(thiophen-2-yl)thiourea analogs for potential cancer immunotherapy. Eur J Med Chem. 2025 Nov 5;297:117968. [Content Brief]

Calculators

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Mass Mass

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Volume Volume

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

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SMU-C68

All Toll-like Receptor (TLR) Isoforms

All NF-κB Isoforms

All p38 MAPK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

SMU-C68 Related Classifications

HY-175293 Related Classifications