SQDG
Based on 1 Customer Validation
SQDG inhibits topoisomerase I and P-selectin receptor, exhibits anti-inflammatory, antiviral and antitumor activities. SQDG is a glycolipid that possesses sugar moieties in their head groups. SQDG is a membrane lipid that can be used to investigate the effects of structural lipid in LNP formulations.
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- Purity: 99.0%
- CAS No.: 123036-44-2
- 화학식: C43H76O12S
- 분자량:817.12
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보관:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
All Topoisomerase Isoforms
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Biological Activity
SQDG is an acidic lipid that can be found in the thylakoid membrane of photosynthetic organisms such as plants and cyanobacteria. SQDG is the composition of the thylakoid membrane, provides a stable environment for membrane proteins and maintains the integrity of the membrane[2].
SQDG binds to four sites of photosystem II (PSII) and affects PSII activity. SQDG regulates the efficiency of photosynthesis. SQDG loss leads to growth inhibition in some cyanobacteria[2].
SQDG inhibits herpes simplex virus type 2 (HSV-1), HSV-2 (IC50=15.6 μg/mL) and Coxsackie virus B3 (Cox B3)[3].
SQDG (0-25 μM, 72 h) exhibits cytotoxicity in acute lymphoblastic leukemia (ALL) cells, IC50s for MOLT-4, MOLT-3 and Reh are 15.32 μM, 22.52 μM and 19.63 μM[4].
SQDG (0-25 μM, 24-48 h) arrests the cell cycle at S phase, and induces apoptosis in MOLT-4 through p53-dependent pathway[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MOLT-4 xenograft mouse models[4]
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Dosage:2 mg/kg
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Administration:ip, two doses in a week
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Result:Inhibited the tumor growth.
Chemical Information
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CAS No. 123036-44-2
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Appearance Solid
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분자량 817.12
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화학식 C43H76O12S
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Color White to light yellow
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SMILES
CC/C=C\C/C=C\C/C=C\CCCCCCCC(OC[C@@H](OC(CCCCCCCCCCCCCCC)=O)CO[C@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CS(=O)(O)=O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
용액&용해도
DMSO : 1 mg/mL (1.22 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Jeonghwan Kim, et al. Naturally Derived Membrane Lipids Impact Nanoparticle-Based Messenger RNA Delivery. Cell Mol Bioeng. 2020 May 26;13(5):463-474. [Content Brief]
[2]. Nakajima Y, et al., Thylakoid membrane lipid sulfoquinovosyl-diacylglycerol (SQDG) is required for full functioning of photosystem II in Thermosynechococcus elongatus. J Biol Chem. 2018 Sep 21;293(38):14786-14797. [Content Brief]
[4]. Jain CK, et al., Sulfonoquinovosyl diacylglyceride selectively targets acute lymphoblastic leukemia cells and exerts potent anti-leukemic effects in vivo. Sci Rep. 2015 Jul 20;5:12082. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2238 mL | 6.1191 mL | 12.2381 mL | 30.5953 mL |
SQDG Related Classifications
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