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Cat. No.: HY-182564

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ST45177901

ST45177901 is a CC chemokine receptor 4 (CCR4) antagonist. The combination of ST45177901 and Sorafenib (HY-10201) effectively inhibits the chemotaxis of Treg cells via the CCL22/CCL17-CCR4 signaling pathway, thereby significantly suppressing the growth and metastasis of tumor cells. ST45177901 is applicable to liver cancer research.

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CAS No.: 618865-88-6
화학식: C₂₆H₁₆ClN₃O₄S₃
분자량:566.07

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

ST45177901 Chemical Structure

CAS No.: 618865-88-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References
Calculators
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Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

CCR4

All CCR Isoforms :

In Vivo

ST45177901 exhibits effects similar to those of C-021 (C-021, when combined with Sorafenib, effectively inhibits hepatocellular carcinoma growth) in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 618865-88-6
분자량 566.07
화학식 C₂₆H₁₆ClN₃O₄S₃
SMILES

O=C(C1=C(C(N(C1C2=CC=CS2)C3=NN=C(SCC4=CC=C(C=C4)Cl)S3)=O)O)C5=CC6=C(C=CC=C6)O5
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Yang, et al. Application of sorafenib combined with CCR4 antagonist for restraining cancer growth and transfer. CN106421796A. China. 2016-11-02.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
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ST45177901

All CCR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

ST45177901 Related Classifications

HY-182564 Related Classifications