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Cat. No.: HY-184099

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Zinilisib

Name: Zinilisib
Brand: MedChemExpress
SKU: HY-184099
Availability: PreOrder

(Synonyms: zinilisibum)

Zinilisib (Zinilisibum) is a PI3K inhibitor. Zinilisib potently inhibits the phosphorylation of AKT in cells expressing mutant PI3Kα^H1047R and wild-type PI3Kα, with IC₅₀ values of 1-500 nM and 2-15 μM, respectively. Zinilisib can be used in breast cancer-related research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 3031974-57-6
화학식: C₂₆H₂₉F₃N₄O₃
분자량:502.53

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Zinilisib Chemical Structure

CAS No.: 3031974-57-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All PI3K Isoforms :

All Akt Isoforms :

In Vitro

Anti-cancerOncogenic Signaling (PI3K, MAPK, Wnt, JAK-STAT)

Anti-cancer

Zinilisib (Example 8) potently inhibits the proliferation of T47D cells expressing mutant PI3Kα^H1047R, with a mean EC₅₀ ranging from 1 nM to 500 nM; it also inhibits the proliferation of SKBR3 cells expressing wild-type PI3Kα, with a mean EC₅₀ ranging from 2 μM to 15 μM^[2].

Anti-cancer

Oncogenic Signaling (PI3K, MAPK, Wnt, JAK-STAT)

Zinilisib (6 h) potently inhibits AKT phosphorylation in T47D cells expressing mutant PI3Kα^H1047R, with a mean IC₅₀ ranging from 1 nM to 500 nM; it also inhibits AKT phosphorylation in SKBR3 cells expressing wild-type PI3Kα, with a mean IC₅₀ ranging from 2 μM to 15 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:

T47D cells expressing mutant PI3Kα (H1047R), SKBR3 cells expressing wild-type PI3Kα
Concentration:

10-point dilution series
Incubation Time:

72 h
Result:

Inhibited proliferation of T47D cells with an average EC₅₀ in the range of 1 nM to 500 nM.
Inhibited proliferation of SKBR3 cells with an average EC₅₀ in the range of 2 μM to 15 μM.

Related Protocols :

Chemical Information

CAS No. 3031974-57-6
분자량 502.53
화학식 C₂₆H₂₉F₃N₄O₃
SMILES

OC(C(C=CC=C1)=C1N[C@@H](C2=C3C(C(N(C(N4CCN(CC4)CC(F)(F)F)=C3)C)=O)=CC(C)=C2)C)=O
Synonyms

zinilisibum
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. International Nonproprietary
Names for Pharmaceutical
Substances (INN). WHO Drug Information, Vol. 39, No. 4, 2025.

[2]. James F, et al. Isoquinolones as pi3k inhibitors. WO2024054469A1. WIPO (PCT). 2023-09-06.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

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Zinilisib

All PI3K Isoforms

All Akt Isoforms