Papain
Based on 17 publication(s) in Google Scholar
Papain is a cysteine protease of the peptidase C1 family. Papain enhances red cell agglutination by anti-D and anti-A, and increases red cell sensitivity to K cell-mediated lysis in ADCC assays. Papain can induce pulmonary emphysema. Papain can be used for the researches of Rh haemolytic disease of the newborn and pulmonary emphysema.
For research use only. We do not sell to patients.
- CAS No.: 9001-73-4
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Papain
More- Bioact Mater. 2022 Jul 20:25:701-715. [Abstract]
- Nat Neurosci. 2023 Dec;26(12):2081-2089. [Abstract]
- Nat Commun. 2025 Mar 8;16(1):2333. [Abstract]
- Acta Pharm Sin B. 2026 Feb 13.
- Acta Pharm Sin B. 2023 Oct;13(10):4318-4336. [Abstract]
- Sci Adv. 2025 Aug;11(31):eadu4270. [Abstract]
- J Neuroinflammation. 2024 Oct 28;21(1):278. [Abstract]
- J Neuroinflammation. 2022 Jun 27;19(1):166. [Abstract]
- Mol Psychiatry. 2025 Sep 16. [Abstract]
- Cell Mol Neurobiol. 2022 May;42(4):1153-1166. [Abstract]
- Life Sci. 2020 Oct 1;258:118099. [Abstract]
- Int Immunopharmacol. 2026 Aug 1:182:116724. [Abstract]
- Behav Brain Res. 2019 Oct 17:372:111950. [Abstract]
- Biochem Biophys Res Commun. 2019 Nov 19;519(4):803-811. [Abstract]
- SSRN. 2026 Jun 8.
- bioRxiv. 2026 Feb 28.
- Research Square Preprint. 2024 Jan 24.
All Cathepsin Isoforms
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Biological Activity
Papain (5 U/mL; 15 min) pretreatment of O Rh-positive red cells enhances anti-D-mediated agglutination, while it slightly reduces anti-A-mediated agglutination of A Rh-negative red cells[2].
Papain (5 U/mL; 15 min) pretreatment of O Rh-positive red cells increases their sensitivity to lymphocyte-mediated lysis in anti-D-mediated ADCC assays at low antibody concentrations and a 15:1 effector-to-target ratio[2].
Papain (5 U/mL; 15 min) pretreatment of O Rh-positive target red cells enables significant PBMC-mediated lysis in anti-D-mediated ADCC assays at a 1:3:3 effector-to-target-to-competitor ratio[2].
Papain (5 U/mL; 15 min) pretreatment of A Rh-negative target red cells enables significant PBMC-mediated lysis in anti-A-mediated ADCC assays at a 1:3:3 effector-to-target-to-competitor ratio[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (female, 20-25 g)[1]
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Dosage:10 IU
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Administration:Intratracheal instillatio; days 0 and 7
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Result:Increased viscoelastic/inhomogeneous pressure, static elastance, and viscoelastic component of elastance.
Increased polymorphonuclear (PMN) cell count, mean alveolar diameter, functional residual capacity (FRC) and decreased elastic fiber area.
Increased KC levels, MIP-2 levels, and IFN-γ levels.
Left TNF-α, IL-1β, and IL-6 levels unchanged relative to saline controls.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 9001-73-4
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Appearance Solid
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Color White to off-white
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SMILES
[Papain]
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Structure Classification
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Initial Source
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Shipping
Shipping with dry ice.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (17)
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Journal Impact Factor
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Most Recent
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Bioact Mater
A bioinspired and high-strengthed hydrogel for regeneration of perforated temporomandibular joint disc: Construction and pleiotropic immunomodulatory effects. [Abstract]2022 Jul 20:25:701-715. PMID: 37056268 -
Nat Neurosci
Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage. [Abstract]2023 Dec;26(12):2081-2089. PMID: 37996529 -
Nat Commun
Maternal behavior promotes resilience to adolescent stress in mice through a microglia-neuron axis. [Abstract]2025 Mar 8;16(1):2333. PMID: 40057602 -
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Acta Pharm Sin B
An injectable bioactive dressing based on platelet-rich plasma and nanoclay: Sustained release of deferoxamine to accelerate chronic wound healing. [Abstract]2023 Oct;13(10):4318-4336. PMID: 37799395 -
Sci Adv
Neuronal Reg3β/macrophage TNF-α-mediated positive feedback signaling contributes to pain chronicity in a rat model of CRPS-I. [Abstract]2025 Aug;11(31):eadu4270. PMID: 40749060 -
J Neuroinflammation
Ganglion cell-derived LysoPS induces retinal neovascularisation by activating the microglial GPR34-PI3K-AKT-NINJ1 axis. [Abstract]2024 Oct 28;21(1):278. PMID: 39468551 -
J Neuroinflammation
Astrocyte reactivation in medial prefrontal cortex contributes to obesity-promoted depressive-like behaviors. [Abstract]2022 Jun 27;19(1):166. PMID: 35761401 -
Mol Psychiatry
Early-life inflammation increases aggressive behavior in adult male mice through an astrocyte-neuron signaling. [Abstract]2025 Sep 16. PMID: 40954280 -
Cell Mol Neurobiol
2022 May;42(4):1153-1166. PMID: 33201418 -
Life Sci
Astrocytes-induced neuronal inhibition contributes to depressive-like behaviors during chronic stress. [Abstract]2020 Oct 1;258:118099. PMID: 32682917 -
Int Immunopharmacol
VEGF-C silencing unlocks therapeutic synergy between MSCs and dexamethasone for osteoarthritis repair. [Abstract]2026 Aug 1:182:116724. PMID: 42096958 -
Behav Brain Res
Dysfunction of astrocytic connexins 30 and 43 in the medial prefrontal cortex and hippocampus mediates depressive-like behaviours. [Abstract]2019 Oct 17:372:111950. PMID: 31103752 -
Biochem Biophys Res Commun
Hippocampal astrocyte dysfunction contributes to etomidate-induced long-lasting synaptic inhibition. [Abstract]2019 Nov 19;519(4):803-811. PMID: 31558319 -
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Solvent & Solubility
H2O : 12.5 mg/mL (Need ultrasonic)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
[1]. Machado MN, et al. Bone Marrow-Derived Mononuclear Cell Therapy in Papain-Induced Experimental Pulmonary Emphysema. Front Physiol. 2018;9:121. Published 2018 Feb 20. [Content Brief]
[2]. Kumpel BM, et al. Comparison of lysis of bromelain and papain treated red cells in ADCC assays. Immunol Lett. 1992;31(3):237-240. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Papain Related Classifications
HY-P1645 Related Classifications
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