country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-163658

Copy Link Print Information

PARP-1-IN-23

PARP-1-IN-23 (Compound I16 ) is an orally active and selective PARP-1 inhibitor with the IC₅₀ of 12.38 nM. PARP-1-IN-23 inhibits tumor growth in vivo.

For research use only. We do not sell to patients.

CAS No.: 2976497-48-8
Formula: C₂₂H₁₈BrN₃O₅S
Molecular Weight:516.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

PARP-1-IN-23 Chemical Structure

CAS No.: 2976497-48-8

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PARP-1-IN-23 (Compound I16 ) is an orally active and selective PARP-1 inhibitor with the IC₅₀ of 12.38 nM. PARP-1-IN-23 inhibits tumor growth in vivo^[1].

IC₅₀ & Target

PARP-1

12.38 nM (IC₅₀)

All PARP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	6.89 μM Compound: I16	Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs	[PMID: 38776379]
C-33-A	IC₅₀	8.05 μM Compound: I16	Antiproliferative activity against human C-33-A cells assessed as inhibition of cell proliferation incubated for 72 hrs Antiproliferative activity against human C-33-A cells assessed as inhibition of cell proliferation incubated for 72 hrs	[PMID: 38776379]
CAPAN-1	IC₅₀	6.79 μM Compound: I16	Antiproliferative activity against human CAPAN-1 cells harboring BRCA1 mutant assessed as inhibition of cell proliferation incubated for 72 hrs Antiproliferative activity against human CAPAN-1 cells harboring BRCA1 mutant assessed as inhibition of cell proliferation incubated for 72 hrs	[PMID: 38776379]
HCC1937	IC₅₀	4.73 μM Compound: I16	Antiproliferative activity against human HCC1937 cells harboring BRCA2 mutant assessed as inhibition of cell proliferation incubated for 72 hrs Antiproliferative activity against human HCC1937 cells harboring BRCA2 mutant assessed as inhibition of cell proliferation incubated for 72 hrs	[PMID: 38776379]
HCT-116	IC₅₀	6.42 μM Compound: I16	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs	[PMID: 38776379]
HeLa	IC₅₀	5.73 μM Compound: I16	Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation incubated for 72 hrs Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation incubated for 72 hrs	[PMID: 38776379]
NCM460	IC₅₀	28.64 μM Compound: I16	Cytotoxicity against human NCM460 cells assessed as inhibition of cell proliferation incubated for 72 hrs Cytotoxicity against human NCM460 cells assessed as inhibition of cell proliferation incubated for 72 hrs	[PMID: 38776379]
SiHa	IC₅₀	8.26 μM Compound: I16	Antiproliferative activity against human SiHa cells assessed as inhibition of cell proliferation incubated for 72 hrs Antiproliferative activity against human SiHa cells assessed as inhibition of cell proliferation incubated for 72 hrs	[PMID: 38776379]
SK-OV-3	IC₅₀	6.67 μM Compound: I16	Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell proliferation incubated for 72 hrs Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell proliferation incubated for 72 hrs	[PMID: 38776379]

Chemical Information

CAS No. 2976497-48-8
Molecular Weight 516.36
Formula C₂₂H₁₈BrN₃O₅S
SMILES

BrC1=CC(C2=NC3=C(C=CC=C3N2)C(N)=O)=CC(OC)=C1OS(=O)(C4=CC=CC=C4C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang Y, et al. Design of Selective PARP-1 Inhibitors and Antitumor Studies. J Med Chem. 2024;67(11):8877-8901. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

Get Quote In-stock