PARP-1-IN-23

Cat. No.: HY-163658: Data Sheet Handling Instructions
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PARP-1-IN-23 (Compound I16 ) is an orally active and selective PARP-1 inhibitor with the IC₅₀ of 12.38 nM. PARP-1-IN-23 inhibits tumor growth in vivo.

For research use only. We do not sell to patients.

PARP-1-IN-23 Chemical Structure

CAS No. : 2976497-48-8

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Description

PARP-1-IN-23 (Compound I16 ) is an orally active and selective PARP-1 inhibitor with the IC₅₀ of 12.38 nM. PARP-1-IN-23 inhibits tumor growth in vivo^[1].

IC₅₀ & Target

PARP-1

12.38 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	6.89 μM Compound: I16	Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs	[PMID: 38776379]
C-33-A	IC₅₀	8.05 μM Compound: I16	Antiproliferative activity against human C-33-A cells assessed as inhibition of cell proliferation incubated for 72 hrs Antiproliferative activity against human C-33-A cells assessed as inhibition of cell proliferation incubated for 72 hrs	[PMID: 38776379]
CAPAN-1	IC₅₀	6.79 μM Compound: I16	Antiproliferative activity against human CAPAN-1 cells harboring BRCA1 mutant assessed as inhibition of cell proliferation incubated for 72 hrs Antiproliferative activity against human CAPAN-1 cells harboring BRCA1 mutant assessed as inhibition of cell proliferation incubated for 72 hrs	[PMID: 38776379]
HCC1937	IC₅₀	4.73 μM Compound: I16	Antiproliferative activity against human HCC1937 cells harboring BRCA2 mutant assessed as inhibition of cell proliferation incubated for 72 hrs Antiproliferative activity against human HCC1937 cells harboring BRCA2 mutant assessed as inhibition of cell proliferation incubated for 72 hrs	[PMID: 38776379]
HCT-116	IC₅₀	6.42 μM Compound: I16	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs	[PMID: 38776379]
HeLa	IC₅₀	5.73 μM Compound: I16	Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation incubated for 72 hrs Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation incubated for 72 hrs	[PMID: 38776379]
NCM460	IC₅₀	28.64 μM Compound: I16	Cytotoxicity against human NCM460 cells assessed as inhibition of cell proliferation incubated for 72 hrs Cytotoxicity against human NCM460 cells assessed as inhibition of cell proliferation incubated for 72 hrs	[PMID: 38776379]
SK-OV-3	IC₅₀	6.67 μM Compound: I16	Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell proliferation incubated for 72 hrs Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell proliferation incubated for 72 hrs	[PMID: 38776379]
SiHa	IC₅₀	8.26 μM Compound: I16	Antiproliferative activity against human SiHa cells assessed as inhibition of cell proliferation incubated for 72 hrs Antiproliferative activity against human SiHa cells assessed as inhibition of cell proliferation incubated for 72 hrs	[PMID: 38776379]

Molecular Weight

516.36

Formula

C₂₂H₁₈BrN₃O₅S

CAS No.

2976497-48-8

SMILES

BrC1=CC(C2=NC3=C(C=CC=C3N2)C(N)=O)=CC(OC)=C1OS(=O)(C4=CC=CC=C4C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang Y, et al. Design of Selective PARP-1 Inhibitors and Antitumor Studies. J Med Chem. 2024;67(11):8877-8901. [Content Brief]

PARP-1-IN-23 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARP-1-IN-232976497-48-8PARPpoly ADP ribose polymeraseSK-OV-3 tumor cell xenograft modelHelaInhibitorinhibitorinhibit

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PARP-1-IN-23

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PARP-1-IN-23 Related Classifications

Molarity Calculator

Dilution Calculator