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Cat. No.: HY-161517

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PARP1-IN-20

PARP1-IN-20 (compound 19A10) is a potent inhibitor of PARP1, with the IC₅₀ of 4.62 nM and has similar low PARP-Trapping effect compared with Veliparib (HY-10129), IC₅₀ (MDA-MB-436) >100 μM.

For research use only. We do not sell to patients.

CAS No.: 2659357-95-4
Formula: C₂₃H₁₉BrN₆O₃S
Molecular Weight:539.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

PARP1-IN-20 Chemical Structure

CAS No.: 2659357-95-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

PARP1

4.62 nM (IC₅₀)

All PARP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HUVEC	IC₅₀	>100 μM Compound: 19A10	Inhibition of cell proliferation in HUVECs Inhibition of cell proliferation in HUVECs	[PMID: 38678823]
MCF7	IC₅₀	>100 μM Compound: 19A10	Inhibition of cell proliferation in human MCF7 cells Inhibition of cell proliferation in human MCF7 cells	[PMID: 38678823]
MDA-MB-436	IC₅₀	>100 μM Compound: 19A10	Inhibition of cell proliferation in human MDA-MB-436 cells assessed as PARP trapping effect Inhibition of cell proliferation in human MDA-MB-436 cells assessed as PARP trapping effect	[PMID: 38678823]

Chemical Information

CAS No. 2659357-95-4
Molecular Weight 539.40
Formula C₂₃H₁₉BrN₆O₃S
SMILES

O=C(N)C1=C2C(NC(C3=CC=C(C(N4CCN(C(C5=CSC(Br)=N5)=O)CC4)=O)C=C3)=N2)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xiaoyu Peng, et al. High affinity and low PARP-trapping benzimidazole derivatives as a potential warhead for PARP1 degraders. Eur J Med Chem. 2024 May 5:271:116405. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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