PI3Kδ-IN-11
PI3Kδ-IN-11 is a highly potent and selective PI3Kδ inhibitor with IC50 value of 27.5 nM. PI3Kδ-IN-11 dose-dependently blocks the activity of PI3K/Akt pathway. PI3Kδ-IN-11 can be used for researching B or T cell-related malignancies.
For research use only. We do not sell to patients.
- CAS No.: 2413257-51-7
- Formula: C27H21N5O
- Molecular Weight:431.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PI3Kδ 27.5 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Raji | IC50 |
8.5 μM
Compound: 15c
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Antiproliferative activity against human Raji cells assessed as inhibition of cell growth after 48 hrs by MTT assay
Antiproliferative activity against human Raji cells assessed as inhibition of cell growth after 48 hrs by MTT assay
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[PMID: 32987316] |
| Ramos | IC50 |
5.4 μM
Compound: 15c
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Antiproliferative activity against human Ramos cells assessed as inhibition of cell growth after 48 hrs by MTT assay
Antiproliferative activity against human Ramos cells assessed as inhibition of cell growth after 48 hrs by MTT assay
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[PMID: 32987316] |
PI3Kδ-IN-11 (compound 15c) (0-10 μM; 48 hours) inhibits Raji and Ramos with IC50s of 8.5 μM and 5.4 μM, respectively[1].
PI3Kδ-IN-11 (0.2-15 μM; 0-48 hours) dampens the proliferation of Raji cells in a dose- and time-dependent manner[1].
PI3Kδ-IN-11 (5 μM; 24 hours) triggers 10.78% apoptosis of cells[1].
PI3Kδ-IN-11 (1-1000 nM; 24 hours) dose-dependently reduces the phosphorylation of Akt (S473)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Raji and Ramos[1]
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Concentration:0-10 μM
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Incubation Time:48 hours
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Result:Inhibited Raji and Ramos with IC50s of 8.5 μM and 5.4 μM, respectively.
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Cell Line:Raji[1]
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Concentration:0.2, 1, 4, 8, 10 and 15 μM
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Incubation Time:0, 12, 24, 36, 48 hours
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Result:Dampened the proliferation of Raji cells in a dose- and time-dependent manner.
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Cell Line:Raji[1]
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Concentration:5 μM
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Incubation Time:24 hours
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Result:Triggered 10.78% apoptosis of cells.
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Cell Line:Raji[1]
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Concentration:1, 10, 100, 500 and 1000 nM
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Incubation Time:24 hours
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Result:Dose-dependently reduced the phosphorylation of Akt (S473), illustrating that the activity of PI3K/Akt pathway was efficiently blocked.
Chemical Information
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CAS No. 2413257-51-7
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Molecular Weight 431.49
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Formula C27H21N5O
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SMILES
C=CC(NC1=CC(NC2=C3C=C(C4=CC5=CC=CC=C5N=C4)C=CC3=NC=N2)=CC=C1C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PI3Kδ-IN-11 Related Classifications
HY-143472 Related Classifications
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