PPARγ agonist 19
PPARγ agonist 19 (Compound 5e) is a PPARγ agonist. PPARγ agonist 19 has an IC50 of 11.27 μM against COX-1 and an IC50 of 0.05 μM against COX-1. PPARγ agonist 19 increases glucose uptake in rat hemidiaphragm assay and is superior to pioglitazone (HY-13956). PPARγ agonist 19 alleviates hyperglycemia and insulin resistance in an in vivo model of type 2 diabetes in rats and protects against renal and lipidemia damage caused by metabolic dysfunction.
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- Formule: C20H17N5O5S3
- Masse moléculaire:503.57
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Activité biologique
Description
IC50 & Target
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PPARγ |
COX-1 11.27 μM (IC50) |
COX-2 0.05 μM (IC50) |
Chemical Information
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Masse moléculaire 503.57
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Formule C20H17N5O5S3
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SMILES
O=S(C1=CC=C(N2N=NC(COC3=CC=C(/C=C(SC(N4)=S)/C4=O)C=C3OC)=C2)C=C1)(N)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PPARγ agonist 19 Related Classifications
HY-176214 Related Classifications
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