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Cat. No.: HY-175224

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PROTAC BRD4 Degrader-36

PROTAC BRD4 Degrader-36 is a BRD4 PROTAC degrader with a DC₅₀ of 0.649 nM. It has a K_d of 123 nM for TRIM21. PROTAC BRD4 Degrader-36 recruits the E3 ubiquitin ligase TRIM21 (K_d= 123 nM) to BRD4, leading to ubiquitination and subsequent degradation of BRD4. PROTAC BRD4 Degrader-36 exhibits cytotoxicity against PANC-1 cells (GI₅₀=0.103 μM). It can be used in research related to pancreatic cancer.
(Pink: BRD4 ligand (HY-129939); Blue: no E3 ligase ligand; Black: linker).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₅₂H₅₈F₂N₆O₇S₃
Masse moléculaire:1013.24

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (280 KB)

PROTAC BRD4 Degrader-36 Chemical Structure

Stock

Quantité

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

PROTAC BRD4 Degrader-36 is a BRD4 PROTAC degrader with a DC₅₀ of 0.649 nM. It has a K_d of 123 nM for TRIM21. PROTAC BRD4 Degrader-36 recruits the E3 ubiquitin ligase TRIM21 (K_d= 123 nM) to BRD4, leading to ubiquitination and subsequent degradation of BRD4. PROTAC BRD4 Degrader-36 exhibits cytotoxicity against PANC-1 cells (GI₅₀=0.103 μM). It can be used in research related to pancreatic cancer^[1]. (Pink: BRD4 ligand (HY-129939); Blue: no E3 ligase ligand; Black: linker).

IC₅₀ & Target

^[1]

BRD4

0.649 nM (DC₅₀)

Voir tous les produits spécifiques à Isoform PROTACs :

Voir tous les produits spécifiques à Isoform Epigenetic Reader Domain :

Cellular Effect

Cell Line	Type	Value	Description	References
PANC-1	DC₅₀	0.649 nM	BRD4 degradation in human PANC-1 cells assessed via high-content analysis (HCA) after 24 hours of incubation. BRD4 degradation in human PANC-1 cells assessed via high-content analysis (HCA) after 24 hours of incubation.	40623734
PANC-1	GI50	0.103 μM	Antiproliferative activity against human PANC-1 cells assessed via antiproliferation assay. Antiproliferative activity against human PANC-1 cells assessed via antiproliferation assay.	40623734

In Vitro

Anti-cancerOthers

Anti-cancer

PROTAC BRD4 Degrader-36 (Compound TrimTAC-1) (0.001-10 μM; 3 days) inhibits the proliferation of PANC-1 cells, with a GI₅₀ value of 0.103 μM^[1].

Others

PROTAC BRD4 Degrader-36 (0.01 nM-10 mM; 24 h) exerts a dose-dependent BRD4 protein degradation effect in PANC-1 cells, with a DC₅₀ of 0.649 nM and a Dmax of 71%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

Masse moléculaire 1013.24
Formule C₅₂H₅₈F₂N₆O₇S₃
SMILES

O=C(C1=C(C=C2C3=CN(C(C4=C3C(CN(C2=C1)C5=NC=C(C=C5F)F)=CN4)=O)C)CS(C)(=O)=O)NCCCCCCCN(CC6CCCCC6)C(C7=C(S(=O)(C)=O)C=C(C=C7)C8=CC=CC=C8SC)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (280 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zhang L, et al. TRIM21-Driven Degradation of BRD4: Development of Heterobifunctional Degraders and Investigation of Recruitment and Selectivity Mechanisms. Journal of chemical information and modeling. 2025 Jul 28;65(14):7584-7604. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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